FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506602661> ?p ?o ?g. }

• W1506602661 endingPage "10796" @default.
• W1506602661 startingPage "10791" @default.
• W1506602661 abstract "Surface proteins of the mammalian stage of the parasitic protozoan, Trypanosoma brucei, were biotinylated with sulfosuccinimidyl 6-(biotinamido) hexanoate. Since the predominant protein labeled by this reagent is the membrane form of the variant surface glycoprotein (mfVSG), a procedure was developed to convert mfVSG to its soluble form by the endogenous glycosylphosphatidylinositol-specific phospholipase C while retaining other biotinylated surface proteins in a membrane-bound state. From these membranes, three novel glycoproteins of 60, 65, and 75 kDa could be isolated by a combination of Triton X-114 phase separation and precipitations by streptavidin and concanavalin A coupled to solid supports. These polypeptides were detected in trypanosomes expressing different mfVSGs and are thus considered to be invariant. In a variant clone in which the mfVSG is trypsin-sensitive, the invariant surface glycoproteins of 65 and 75 kDa, designated ISG65 and ISG75, respectively, were proteolytically degraded with similar kinetics as the mfVSG. Neither ISG65 nor ISG75 could be detected in procyclic trypanosomes, the stage of the parasite characteristic for the insect midgut. Gene cloning reported in the accompanying paper (Ziegelbauer, K., Multhaup, G., and Overath, P. (1992) J. Biol. Chem. 267, 10797-10803) suggests that ISG65 and ISG75 are transmembrane proteins." @default.
• W1506602661 created "2016-06-24" @default.
• W1506602661 creator A5038854091 @default.
• W1506602661 creator A5051451842 @default.
• W1506602661 date "1992-05-01" @default.
• W1506602661 modified "2023-10-18" @default.
• W1506602661 title "Identification of invariant surface glycoproteins in the bloodstream stage of Trypanosoma brucei." @default.
• W1506602661 cites W133055361 @default.
• W1506602661 cites W1491162763 @default.
• W1506602661 cites W1497445703 @default.
• W1506602661 cites W1598750267 @default.
• W1506602661 cites W1669620629 @default.
• W1506602661 cites W1711095524 @default.
• W1506602661 cites W1741609474 @default.
• W1506602661 cites W1949772429 @default.
• W1506602661 cites W1967273744 @default.
• W1506602661 cites W1970272453 @default.
• W1506602661 cites W1972653235 @default.
• W1506602661 cites W1973217987 @default.
• W1506602661 cites W1976605236 @default.
• W1506602661 cites W1981600594 @default.
• W1506602661 cites W1986367195 @default.
• W1506602661 cites W1987617311 @default.
• W1506602661 cites W1992760440 @default.
• W1506602661 cites W1993305231 @default.
• W1506602661 cites W1993789732 @default.
• W1506602661 cites W1996981200 @default.
• W1506602661 cites W1998287259 @default.
• W1506602661 cites W2019835723 @default.
• W1506602661 cites W2025143436 @default.
• W1506602661 cites W2025875629 @default.
• W1506602661 cites W2027097213 @default.
• W1506602661 cites W2030964506 @default.
• W1506602661 cites W2047799290 @default.
• W1506602661 cites W2056544226 @default.
• W1506602661 cites W2075127103 @default.
• W1506602661 cites W2085740119 @default.
• W1506602661 cites W2091749237 @default.
• W1506602661 cites W2097439203 @default.
• W1506602661 cites W2100837269 @default.
• W1506602661 cites W2112367962 @default.
• W1506602661 cites W2143381397 @default.
• W1506602661 cites W2169317674 @default.
• W1506602661 cites W2277343795 @default.
• W1506602661 cites W2346343787 @default.
• W1506602661 cites W2743792571 @default.
• W1506602661 doi "https://doi.org/10.1016/s0021-9258(19)50088-6" @default.
• W1506602661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1587855" @default.
• W1506602661 hasPublicationYear "1992" @default.
• W1506602661 type Work @default.
• W1506602661 sameAs 1506602661 @default.
• W1506602661 citedByCount "94" @default.
• W1506602661 countsByYear W15066026612012 @default.
• W1506602661 countsByYear W15066026612013 @default.
• W1506602661 countsByYear W15066026612014 @default.
• W1506602661 countsByYear W15066026612015 @default.
• W1506602661 countsByYear W15066026612016 @default.
• W1506602661 countsByYear W15066026612017 @default.
• W1506602661 countsByYear W15066026612018 @default.
• W1506602661 countsByYear W15066026612019 @default.
• W1506602661 countsByYear W15066026612020 @default.
• W1506602661 countsByYear W15066026612021 @default.
• W1506602661 countsByYear W15066026612022 @default.
• W1506602661 countsByYear W15066026612023 @default.
• W1506602661 crossrefType "journal-article" @default.
• W1506602661 hasAuthorship W1506602661A5038854091 @default.
• W1506602661 hasAuthorship W1506602661A5051451842 @default.
• W1506602661 hasBestOaLocation W15066026611 @default.
• W1506602661 hasConcept C104317684 @default.
• W1506602661 hasConcept C108625454 @default.
• W1506602661 hasConcept C116834253 @default.
• W1506602661 hasConcept C159047783 @default.
• W1506602661 hasConcept C2779502636 @default.
• W1506602661 hasConcept C2779549974 @default.
• W1506602661 hasConcept C55493867 @default.
• W1506602661 hasConcept C59822182 @default.
• W1506602661 hasConcept C70721500 @default.
• W1506602661 hasConcept C86803240 @default.
• W1506602661 hasConcept C95444343 @default.
• W1506602661 hasConceptScore W1506602661C104317684 @default.
• W1506602661 hasConceptScore W1506602661C108625454 @default.
• W1506602661 hasConceptScore W1506602661C116834253 @default.
• W1506602661 hasConceptScore W1506602661C159047783 @default.
• W1506602661 hasConceptScore W1506602661C2779502636 @default.
• W1506602661 hasConceptScore W1506602661C2779549974 @default.
• W1506602661 hasConceptScore W1506602661C55493867 @default.
• W1506602661 hasConceptScore W1506602661C59822182 @default.
• W1506602661 hasConceptScore W1506602661C70721500 @default.
• W1506602661 hasConceptScore W1506602661C86803240 @default.
• W1506602661 hasConceptScore W1506602661C95444343 @default.
• W1506602661 hasIssue "15" @default.
• W1506602661 hasLocation W15066026611 @default.
• W1506602661 hasOpenAccess W1506602661 @default.
• W1506602661 hasPrimaryLocation W15066026611 @default.
• W1506602661 hasRelatedWork W190131006 @default.
• W1506602661 hasRelatedWork W1976196322 @default.
• W1506602661 hasRelatedWork W2029403688 @default.
• W1506602661 hasRelatedWork W2088663136 @default.

• next