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- W1506670497 abstract "Abstract Thymus function decreases with aging. This is accompanied by changes in thymocyte composition, related to different rates of involution of cortex and medulla. One cause may be an improper microenvironment for T-cell differentiation. A function of the thymus microenvironment is secretion of thymic factors, one of which is human thymic epithelial-conditioned medium (HTECM). In this study we investigated whether activity of HTECM on mitogen response of mouse thymocytes could be related to the age of the thymus donor. The activity of HTECM appeared to be highest when obtained from thymic epithelial cultures of donors around 20 years; thereafter the effect of HTECM declined. HTECM obtained from epithelial cultures of pathologic thymus tissue displayed various effects. HTECM from hyperplastic thymus showed the same or high activity related to that from age-matched normal thymus. HTECM derived from cultured thymic tumors gave no to very high activity." @default.
- W1506670497 created "2016-06-24" @default.
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- W1506670497 date "1981-02-01" @default.
- W1506670497 modified "2023-09-26" @default.
- W1506670497 title "The thymus in the aging individual" @default.
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- W1506670497 doi "https://doi.org/10.1016/0090-1229(81)90025-8" @default.
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