FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506719196> ?p ?o ?g. }

• W1506719196 endingPage "5701" @default.
• W1506719196 startingPage "5693" @default.
• W1506719196 abstract "Abstract Thrombosis is a prominent feature of acute vascular rejection (AVR), the current barrier to survival of pig-to-primate xenografts. Fibrinogen-like protein 2 (fgl2/fibroleukin) is an inducible prothrombinase that plays an important role in the pathogenesis of fibrin deposition during viral hepatitis and cytokine-induced fetal loss. We hypothesized that induction of fgl2 on the vascular endothelium of xenografts contributes to thrombosis associated with AVR. We first examined fgl2 as a source of procoagulant activity in the pig-to-primate combination. The porcine fgl2 (pfgl2) was cloned and its chromosomal locus was identified. Recombinant pfgl2 protein expressed in vitro was detected on the cell surface and generated thrombin from human prothrombin. Studies of pig-to-baboon kidney xenografts undergoing AVR in vivo revealed induction of pfgl2 expression on graft vascular endothelial cells (ECs). Cultured porcine ECs activated by human TNF-α in vitro demonstrated induction of pfgl2 expression and enhanced activation of human prothrombin. The availability of gene-targeted fgl2-deficient mice allowed the contribution of fgl2 to the pathogenesis of AVR to be directly examined in vivo. Hearts heterotopically transplanted from fgl2+/+ and fgl2+/− mice into Lewis rats developed AVR with intravascular thrombosis associated with induction of fgl2 in graft vascular ECs. In contrast, xenografts from fgl2−/− mice were devoid of thrombosis. These observations collectively suggest that induction of fgl2 on the vascular endothelium plays a role in the pathogenesis of AVR-associated thrombosis. Manipulation of fgl2, in combination with other interventions, may yield novel strategies by which to overcome AVR and extend xenograft survival." @default.
• W1506719196 created "2016-06-24" @default.
• W1506719196 creator A5000205473 @default.
• W1506719196 creator A5019622311 @default.
• W1506719196 creator A5020449897 @default.
• W1506719196 creator A5059325717 @default.
• W1506719196 creator A5073401589 @default.
• W1506719196 creator A5085662959 @default.
• W1506719196 creator A5087030035 @default.
• W1506719196 creator A5088664989 @default.
• W1506719196 creator A5089678884 @default.
• W1506719196 date "2004-05-01" @default.
• W1506719196 modified "2023-10-16" @default.
• W1506719196 title "Endothelial Induction of fgl2 Contributes to Thrombosis during Acute Vascular Xenograft Rejection" @default.
• W1506719196 cites W1551650257 @default.
• W1506719196 cites W1607326420 @default.
• W1506719196 cites W1659248918 @default.
• W1506719196 cites W1950085922 @default.
• W1506719196 cites W1969380932 @default.
• W1506719196 cites W1971016055 @default.
• W1506719196 cites W1975310803 @default.
• W1506719196 cites W1981107148 @default.
• W1506719196 cites W1992339842 @default.
• W1506719196 cites W1993278131 @default.
• W1506719196 cites W1997076203 @default.
• W1506719196 cites W2007516625 @default.
• W1506719196 cites W2009183800 @default.
• W1506719196 cites W2012574456 @default.
• W1506719196 cites W2015540930 @default.
• W1506719196 cites W2018204952 @default.
• W1506719196 cites W2021300163 @default.
• W1506719196 cites W2022186492 @default.
• W1506719196 cites W2027880172 @default.
• W1506719196 cites W2028498948 @default.
• W1506719196 cites W2029055264 @default.
• W1506719196 cites W2036029448 @default.
• W1506719196 cites W2051773355 @default.
• W1506719196 cites W2052816795 @default.
• W1506719196 cites W2067846827 @default.
• W1506719196 cites W2071943691 @default.
• W1506719196 cites W2084836597 @default.
• W1506719196 cites W2086476311 @default.
• W1506719196 cites W2087544700 @default.
• W1506719196 cites W2092178015 @default.
• W1506719196 cites W2104810826 @default.
• W1506719196 cites W2110553915 @default.
• W1506719196 cites W2123315870 @default.
• W1506719196 cites W2131549241 @default.
• W1506719196 cites W2145685346 @default.
• W1506719196 cites W2148184264 @default.
• W1506719196 cites W2155657052 @default.
• W1506719196 cites W2239996587 @default.
• W1506719196 cites W4313377193 @default.
• W1506719196 doi "https://doi.org/10.4049/jimmunol.172.9.5693" @default.
• W1506719196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15100314" @default.
• W1506719196 hasPublicationYear "2004" @default.
• W1506719196 type Work @default.
• W1506719196 sameAs 1506719196 @default.
• W1506719196 citedByCount "92" @default.
• W1506719196 countsByYear W15067191962012 @default.
• W1506719196 countsByYear W15067191962013 @default.
• W1506719196 countsByYear W15067191962014 @default.
• W1506719196 countsByYear W15067191962015 @default.
• W1506719196 countsByYear W15067191962016 @default.
• W1506719196 countsByYear W15067191962017 @default.
• W1506719196 countsByYear W15067191962018 @default.
• W1506719196 countsByYear W15067191962019 @default.
• W1506719196 countsByYear W15067191962020 @default.
• W1506719196 countsByYear W15067191962021 @default.
• W1506719196 countsByYear W15067191962023 @default.
• W1506719196 crossrefType "journal-article" @default.
• W1506719196 hasAuthorship W1506719196A5000205473 @default.
• W1506719196 hasAuthorship W1506719196A5019622311 @default.
• W1506719196 hasAuthorship W1506719196A5020449897 @default.
• W1506719196 hasAuthorship W1506719196A5059325717 @default.
• W1506719196 hasAuthorship W1506719196A5073401589 @default.
• W1506719196 hasAuthorship W1506719196A5085662959 @default.
• W1506719196 hasAuthorship W1506719196A5087030035 @default.
• W1506719196 hasAuthorship W1506719196A5088664989 @default.
• W1506719196 hasAuthorship W1506719196A5089678884 @default.
• W1506719196 hasBestOaLocation W15067191961 @default.
• W1506719196 hasConcept C112516734 @default.
• W1506719196 hasConcept C126322002 @default.
• W1506719196 hasConcept C142724271 @default.
• W1506719196 hasConcept C17991360 @default.
• W1506719196 hasConcept C186738567 @default.
• W1506719196 hasConcept C203014093 @default.
• W1506719196 hasConcept C2776992346 @default.
• W1506719196 hasConcept C2777292125 @default.
• W1506719196 hasConcept C2778382381 @default.
• W1506719196 hasConcept C2780868729 @default.
• W1506719196 hasConcept C2780942790 @default.
• W1506719196 hasConcept C71924100 @default.
• W1506719196 hasConcept C86803240 @default.
• W1506719196 hasConcept C89560881 @default.
• W1506719196 hasConceptScore W1506719196C112516734 @default.
• W1506719196 hasConceptScore W1506719196C126322002 @default.
• W1506719196 hasConceptScore W1506719196C142724271 @default.

• next