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- W1506815516 abstract "Abstract The effect of exogenous glucosamine on the incorporation of lysine-14C, uridine-14C, and thymidine-14C into various normal and experimental tumor tissues was studied. Glucosamine at high concentrations markedly inhibited the incorporation of these precursors into protein, RNA, and DNA of Walker carcinosarcoma 256 of rats and of sarcoma 180 and C3H spontaneous mammary tumor of mice. Glucose or pyruvate did not reverse the inhibition by glucosamine. The effect of exogenous glucosamine in vitro on the incorporation of the labeled precursors into normal tissues was much less than that into neoplastic tissues. N-Acetylglucosamine and many other sugars tested showed little inhibition of protein, RNA, and DNA synthesis. The only inhibitory sugars, other than glucosamine, were D-mannosamine, D-galactosamine, and D-mannose." @default.
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- W1506815516 date "1969-07-01" @default.
- W1506815516 modified "2023-09-27" @default.
- W1506815516 title "Inhibitory Effect of D-Glucosamine and Other Sugars on the Biosynthesis of Protein, Ribonucleic Acid, and Deoxyribonucleic Acid in Normal and Neoplastic Tissues" @default.
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- W1506815516 doi "https://doi.org/10.1016/s0021-9258(17)36416-5" @default.
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