Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506822304> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1506822304 abstract "Abstract : To explore two new neuroprotective strategies in the setting of experimental repetitive mild traumatic brain injury (mTBI): i) hyperbaric oxygen (HBO) preconditioning and ii) HBO treatment combined with intranasal delivery of nicotinamide (Vitamin B3). Scope: In rat model of a repetitive mild cortical controlled injury, we will investigate the neuropathological profile of two mTBI sessions at two interval times (3, 7d) using non-invasive MRI assessments (T2WI, SWI, and DTI), correlated with histology. The effects of i) a prophylactic HBO strategy (pretreatment 3d X 1hr) prior to first mTBI and ii) the comprehensive therapeutic strategy of 3d X 1hr course of HBO combined with intranasal administration of nicotinamide right after the first mTBI impact will be evaluated using the MRI and histological biomarkers. Major Findings: Two sessions of mTBI with 3d apart resulted in significant increase in lesion volumes derived from T2WI and hemorrhagic lesion derived from SWI. Ex vivo histology examination confirms the in vivo neuroimaging findings. HBO pretreatment significantly reduced the lesion volume and hemorrhagic lesion in rmTBI with either 3d or 7d apart. Progress Report: There is cumulative neuropathology following repetitive mTBI. The initial mTBI event renders the brain vulnerable to the subsequent mTBI up to 3 days. HBO pretreatment prior to the initial mTBI appears to prevent the detrimental consequences of either single mTBI or repetitive mTBI events." @default.
- W1506822304 created "2016-06-24" @default.
- W1506822304 creator A5054373762 @default.
- W1506822304 date "2010-06-01" @default.
- W1506822304 modified "2023-09-23" @default.
- W1506822304 title "Neuroprotective Strategies After Repetitive Mild Traumatic Brain Injury (mTBI)" @default.
- W1506822304 doi "https://doi.org/10.21236/ada542080" @default.
- W1506822304 hasPublicationYear "2010" @default.
- W1506822304 type Work @default.
- W1506822304 sameAs 1506822304 @default.
- W1506822304 citedByCount "0" @default.
- W1506822304 crossrefType "report" @default.
- W1506822304 hasAuthorship W1506822304A5054373762 @default.
- W1506822304 hasConcept C118552586 @default.
- W1506822304 hasConcept C126322002 @default.
- W1506822304 hasConcept C141071460 @default.
- W1506822304 hasConcept C190385971 @default.
- W1506822304 hasConcept C25498285 @default.
- W1506822304 hasConcept C2778426673 @default.
- W1506822304 hasConcept C2781017439 @default.
- W1506822304 hasConcept C2781156865 @default.
- W1506822304 hasConcept C3017944768 @default.
- W1506822304 hasConcept C42219234 @default.
- W1506822304 hasConcept C71924100 @default.
- W1506822304 hasConcept C99454951 @default.
- W1506822304 hasConceptScore W1506822304C118552586 @default.
- W1506822304 hasConceptScore W1506822304C126322002 @default.
- W1506822304 hasConceptScore W1506822304C141071460 @default.
- W1506822304 hasConceptScore W1506822304C190385971 @default.
- W1506822304 hasConceptScore W1506822304C25498285 @default.
- W1506822304 hasConceptScore W1506822304C2778426673 @default.
- W1506822304 hasConceptScore W1506822304C2781017439 @default.
- W1506822304 hasConceptScore W1506822304C2781156865 @default.
- W1506822304 hasConceptScore W1506822304C3017944768 @default.
- W1506822304 hasConceptScore W1506822304C42219234 @default.
- W1506822304 hasConceptScore W1506822304C71924100 @default.
- W1506822304 hasConceptScore W1506822304C99454951 @default.
- W1506822304 hasLocation W15068223041 @default.
- W1506822304 hasOpenAccess W1506822304 @default.
- W1506822304 hasPrimaryLocation W15068223041 @default.
- W1506822304 hasRelatedWork W1026887136 @default.
- W1506822304 hasRelatedWork W1999024269 @default.
- W1506822304 hasRelatedWork W2017348110 @default.
- W1506822304 hasRelatedWork W2031031509 @default.
- W1506822304 hasRelatedWork W2150941374 @default.
- W1506822304 hasRelatedWork W2461647519 @default.
- W1506822304 hasRelatedWork W2555065331 @default.
- W1506822304 hasRelatedWork W2766083709 @default.
- W1506822304 hasRelatedWork W2781511116 @default.
- W1506822304 hasRelatedWork W2804408020 @default.
- W1506822304 hasRelatedWork W2891137927 @default.
- W1506822304 hasRelatedWork W2892074141 @default.
- W1506822304 hasRelatedWork W2938558093 @default.
- W1506822304 hasRelatedWork W2989007939 @default.
- W1506822304 hasRelatedWork W3012397410 @default.
- W1506822304 hasRelatedWork W3016022290 @default.
- W1506822304 hasRelatedWork W3118236223 @default.
- W1506822304 hasRelatedWork W3152174881 @default.
- W1506822304 hasRelatedWork W3171340263 @default.
- W1506822304 hasRelatedWork W1664608847 @default.
- W1506822304 isParatext "false" @default.
- W1506822304 isRetracted "false" @default.
- W1506822304 magId "1506822304" @default.
- W1506822304 workType "report" @default.