Matches in SemOpenAlex for { <https://semopenalex.org/work/W1506857568> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1506857568 endingPage "516" @default.
- W1506857568 startingPage "510" @default.
- W1506857568 abstract "BACKGROUND: Previously, we evaluated the Mirasol pathogen reduction technology (PRT) system on platelet (PLT) function before resuspension. We now evaluated this system in the presence of PLT additive solution (PAS). STUDY DESIGN AND METHODS: Double-dose PLTs (n = 15) were generated using a commercially available apheresis system (Trima, Version 5.2, CaridianBCT) allowing for the resuspension in SSP+ (MacoPharma) immediately after collection. Paired units (n = 30) were PRT treated (M) or remained untreated (C) and analyzed for metabolism (pH, pO2, glucose, lactate, adenosine triphosphate [ATP]), swirl, hypotonic shock response (HSR), turbidometric aggregation, CD62P expression, annexin A5 and lactate dehydrogenase (LDH) release, mitochondrial enzymatic reduction activity (MTS), transmembrane mitochondrial potential (Δψ), and surface coverage (SC) during shear-induced adhesion throughout 8 days of storage. RESULTS: As seen previously, PRT treatment of PLT units, containing a mean of 3.9 × 1011 ± 0.3 × 1011 PLTs in 397 ± 10 mL with a 32% to 34% plasma carryover, was associated with significantly (p < 0.001) increased cell activation, acidity, and glycolytic flux. PRT treatment appeared to up regulate both oxidative pathway and adhesional properties as evidenced by significantly higher MTS reduction, oxygen consumption, and shear-induced SC on Day 1 (p ≤ 0.016). While no significant differences were found for LDH release and ATP content (except for Day 8), M units were significantly inferior (p ≤ 0.021) for aggregation (TRAP-6); for Δψ and annexin A5 release (by Day 5); and for swirl, HSR, and MTS reduction (by Day 7). CONCLUSION: PRT treatment in the presence of PAS was comparable to PRT treatment before resuspension preserving ATP content and mitochondrial function." @default.
- W1506857568 created "2016-06-24" @default.
- W1506857568 creator A5036443573 @default.
- W1506857568 creator A5067390797 @default.
- W1506857568 creator A5082820558 @default.
- W1506857568 date "2011-10-07" @default.
- W1506857568 modified "2023-09-24" @default.
- W1506857568 title "Cell quality of apheresis-derived platelets treated with riboflavin-ultraviolet light after resuspension in platelet additive solution" @default.
- W1506857568 cites W13535085 @default.
- W1506857568 cites W1876522613 @default.
- W1506857568 cites W1891875833 @default.
- W1506857568 cites W1966197810 @default.
- W1506857568 cites W1979222495 @default.
- W1506857568 cites W2002911644 @default.
- W1506857568 cites W2030868440 @default.
- W1506857568 cites W2050526002 @default.
- W1506857568 cites W2053063776 @default.
- W1506857568 cites W2064420125 @default.
- W1506857568 cites W2072734698 @default.
- W1506857568 cites W2074467918 @default.
- W1506857568 cites W2075002476 @default.
- W1506857568 cites W2078328099 @default.
- W1506857568 cites W2093254821 @default.
- W1506857568 cites W2097893807 @default.
- W1506857568 cites W2119224753 @default.
- W1506857568 cites W2126312544 @default.
- W1506857568 cites W2153270908 @default.
- W1506857568 cites W4243492021 @default.
- W1506857568 doi "https://doi.org/10.1111/j.1537-2995.2011.03323.x" @default.
- W1506857568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21981030" @default.
- W1506857568 hasPublicationYear "2011" @default.
- W1506857568 type Work @default.
- W1506857568 sameAs 1506857568 @default.
- W1506857568 citedByCount "24" @default.
- W1506857568 countsByYear W15068575682014 @default.
- W1506857568 countsByYear W15068575682015 @default.
- W1506857568 countsByYear W15068575682016 @default.
- W1506857568 countsByYear W15068575682018 @default.
- W1506857568 countsByYear W15068575682019 @default.
- W1506857568 countsByYear W15068575682020 @default.
- W1506857568 countsByYear W15068575682021 @default.
- W1506857568 countsByYear W15068575682022 @default.
- W1506857568 crossrefType "journal-article" @default.
- W1506857568 hasAuthorship W1506857568A5036443573 @default.
- W1506857568 hasAuthorship W1506857568A5067390797 @default.
- W1506857568 hasAuthorship W1506857568A5082820558 @default.
- W1506857568 hasConcept C126322002 @default.
- W1506857568 hasConcept C16685009 @default.
- W1506857568 hasConcept C181199279 @default.
- W1506857568 hasConcept C185592680 @default.
- W1506857568 hasConcept C2776738589 @default.
- W1506857568 hasConcept C2777318727 @default.
- W1506857568 hasConcept C2778917026 @default.
- W1506857568 hasConcept C2779564974 @default.
- W1506857568 hasConcept C55493867 @default.
- W1506857568 hasConcept C71924100 @default.
- W1506857568 hasConcept C89560881 @default.
- W1506857568 hasConceptScore W1506857568C126322002 @default.
- W1506857568 hasConceptScore W1506857568C16685009 @default.
- W1506857568 hasConceptScore W1506857568C181199279 @default.
- W1506857568 hasConceptScore W1506857568C185592680 @default.
- W1506857568 hasConceptScore W1506857568C2776738589 @default.
- W1506857568 hasConceptScore W1506857568C2777318727 @default.
- W1506857568 hasConceptScore W1506857568C2778917026 @default.
- W1506857568 hasConceptScore W1506857568C2779564974 @default.
- W1506857568 hasConceptScore W1506857568C55493867 @default.
- W1506857568 hasConceptScore W1506857568C71924100 @default.
- W1506857568 hasConceptScore W1506857568C89560881 @default.
- W1506857568 hasIssue "3" @default.
- W1506857568 hasLocation W15068575681 @default.
- W1506857568 hasLocation W15068575682 @default.
- W1506857568 hasOpenAccess W1506857568 @default.
- W1506857568 hasPrimaryLocation W15068575681 @default.
- W1506857568 hasRelatedWork W2046194315 @default.
- W1506857568 hasRelatedWork W2065211824 @default.
- W1506857568 hasRelatedWork W2089807886 @default.
- W1506857568 hasRelatedWork W2090758904 @default.
- W1506857568 hasRelatedWork W2350482501 @default.
- W1506857568 hasRelatedWork W2350783077 @default.
- W1506857568 hasRelatedWork W2359420987 @default.
- W1506857568 hasRelatedWork W2361645227 @default.
- W1506857568 hasRelatedWork W2378716375 @default.
- W1506857568 hasRelatedWork W2386119347 @default.
- W1506857568 hasVolume "52" @default.
- W1506857568 isParatext "false" @default.
- W1506857568 isRetracted "false" @default.
- W1506857568 magId "1506857568" @default.
- W1506857568 workType "article" @default.