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• W1506875428 abstract "Peroxynitrite (ONOO(-)) is a potent oxidant formed by the nonenzymatic reaction between superoxide anion (O(2)(*-)) and nitric oxide (NO*) in a one-to-one stoichiometry. Accumulated evidence suggests that endothelial dysfunction coincides with an enhanced NO* synthase expression and O(2)(*-) production, facilitating ONOO(-) formation. In vivo, formation of ONOO(-) has been associated with atherosclerosis and vascular aging. The immunosuppressor Cyclosporine A (CsA) has been associated to human endothelial dysfunction and accelerated atherosclerosis. We have previously shown that CsA induced a transcriptionally mediated increase of the eNOS gene expression and that CsA induced the formation of nitric oxide, O(2)(*-), and ONOO(-) in vascular endothelial cells. In this work, we evaluate the CsA-induced relative amounts of formation of O(2)(*-) and NO*, providing data consistent with a role of O(2)(*-), and not NO*, as the limiting factor in the CsA-dependent intracellular formation of ONOO(-) in vascular endothelial cells. Furthermore, when endothelial cells were treated with CsA in a situation of increased generation of superoxide such as that provided by high glucose levels, a further increase in the formation of peroxynitrite was detected. The temporal availability of O(2)(*-) for peroxynitrite formation may thus become critical in the pathophysiological scenarios where reactive nitrogen intermediates are operative." @default.
• W1506875428 created "2016-06-24" @default.
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• W1506875428 date "2002-04-01" @default.
• W1506875428 modified "2023-10-17" @default.
• W1506875428 title "Superoxide limits cyclosporine-A-induced formation of peroxynitrite in endothelial cells2 2Part of this article has been previously published in abstract form in the 6th International Symposium on spin trapping, “Spin Traps, Nitroxides and Nitric Oxide: Spectroscopy, Chemistry and Free Radical Biology,” August 27–31, 2000, Marseille, France. Abstract book page 48." @default.
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• W1506875428 doi "https://doi.org/10.1016/s0891-5849(02)00761-x" @default.
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