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- W1506876742 abstract "Abstract Subunit II of cytochrome c oxidase is a mitochondrially encoded protein required for cellular respiration. A respiration-deficient yeast strain has been isolated and shown genetically to carry a mutation in the subunit II structural gene COX2. The respiration-deficient strain produces no subunit II polypeptide and is missing two major transcripts of the subunit II gene. The mutation, first mapped by rho- recombinational rescue to the 5' end of the gene, has been localized precisely, by DNA sequencing, 58 nucleotides upstream of the COX2 ATG initiation codon. The mutant strain carries a single nucleotide change (A to T) relative to the wild type sequence. This mutation occurs in a sequence with substantial homology to a previously identified yeast mitochondrial promoter consensus sequence. These results provide the first in vivo evidence for the importance of the consensus sequence for promoter function." @default.
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- W1506876742 date "1989-08-01" @default.
- W1506876742 modified "2023-09-28" @default.
- W1506876742 title "Isolation and Characterization of a Yeast Strain Carrying a Mutation in the Mitochondrial Promoter for COX2" @default.
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- W1506876742 doi "https://doi.org/10.1016/s0021-9258(18)80007-2" @default.
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