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- W1507029585 abstract "Breast cancer is one of the major causes of cancer-related death for women throughout the world. Although the early detection of breast cancer is improving, the strategies available to treat the advanced stages of this disease remain limited. Therefore, the identification of key molecules that regulate the metastatic process is necessary to provide the rationale for further therapeutic interventions. The IGF2 mRNA-binding Protein 2 (IMP2/IGF2BP2/p62) is a member of the IMP family. Expression of IMPs in cancer cells is associated with cancer progression. Our previous studies showed that p62/IMP2 is overexpressed in breast cancer tissue compared to the adjacent normal breast tissue. However, the role of p62/IMP2 in breast cancer progression remains unknown. Here, we present evidence that transfection of p62/IMP2 into two p62/IMP2 negative cell lines (MDA-MB-231 and MCF7) increases 5 to 10 folds (P Our analysis shows that the overexpression of p62/IMP2 leads to increased c-myc expression in MDA-MB-231 cells but not MCF-7 cells at both the transcriptional and translational levels. In contrast, beta-catenin expression is increased by p62/IMP2 only in MCF7 cells. Since c-myc and beta-catenin gene products are important regulators of metastasis in breast cancer, and their increased expression is observed in our p62/IMP2 transfectants, our data suggests that p62/IMP2 may be an important mediator of breast cancer progression, although its mechanism of action may vary depending on the cellular context in which it is expressed. Citation Format: Yang Li, Bo Peng, Jing Ning, Wei Qian, Gulio Francia, Jianying Zhang. p62/IMP2 promotes breast cancer cell progression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5573. doi:10.1158/1538-7445.AM2014-5573" @default.
- W1507029585 created "2016-06-24" @default.
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- W1507029585 date "2014-09-30" @default.
- W1507029585 modified "2023-09-26" @default.
- W1507029585 title "Abstract 5573: p62/IMP2 promotes breast cancer cell progression" @default.
- W1507029585 doi "https://doi.org/10.1158/1538-7445.am2014-5573" @default.
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