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- W150706787 abstract "This chapter provides a brief summary of recommendations regarding current standards for the diagnosis of amyloidosis and outlines practical considerations and advice on the available options. Congo red stain continues to be the generally accepted standard in amyloid detection. However, successful application of this stain is dependent on many variables, including preanalytical steps, technical issues associated with stain performance, and its interpretation which also requires considerable experience on the part of the observer. All of these factors make the routine use of Congo red stain in general surgical pathology difficult and error prone. In this chapter, technical issues associated with the Congo red stain and polarization, including the thickness of the sections, are summarized. Advantages and disadvantages of the use of other stains, in particular Congo red fluorescence and Thioflavin stains, are also discussed. Technical issues associated with the utilization of fat biopsy for amyloid detection and staging are also considered. The detection of amyloid in tissue sections, which is considered to be the initial and the most critical step in the management of patients with amyloidosis, is entirely dependent upon the skill of the pathologist. Hence, there is an urgent need to increase the level of expertise applied in the diagnosis of amyloidosis among surgical pathologists and a need to concentrate on early detection." @default.
- W150706787 created "2016-06-24" @default.
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- W150706787 date "2012-01-01" @default.
- W150706787 modified "2023-10-17" @default.
- W150706787 title "Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editorial Comments on Chaps. 12–15" @default.
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- W150706787 doi "https://doi.org/10.1007/978-1-60761-389-3_16" @default.
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