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- W1507092067 abstract "This chapter describes sequential requirement of retinoic acid treatment and of expression of peroxisome proliferative-activated receptor (PPAR) gamma and leukemia inhibitory factor (LIF) receptor to induce adipogenesis of embryonic stem (ES) cells. The ongoing global explosion in the incidence of obesity has thus focused attention on the development of adipose cells. The key events leading to terminal differentiation of preadipocytes into adipocytes have been characterized in recent years by the identification of transcription factors that play a regulatory role in the differentiation process. Severe obesity is the result of an increase in fat cell size in combination with increased fat cell number. Mature adipocytes do not undergo cell division and new fat cells arise from a preexisting pool of adipose stem cells that are present irrespective of age. Development of established preadipose cell lines has facilitated the study of the different steps leading to terminal differentiation of preadipocytes into adipocytes. However, these systems are limited for studying early events of differentiation because they represent cells that are already determined for adipogenic lineage. Masters genes that commit multipotent stem cells toward adipocytes remain to be identified." @default.
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- W1507092067 date "2004-01-01" @default.
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- W1507092067 title "Differentiation of Embryonic Stem Cells into Adipose Cells" @default.
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