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- W1507147712 abstract "Natural selection for nutrients results in their metabolism to pheromones that control reproduction in species from microbes to man. In some species, sex differences in pheromones enable sexual selection. Using what is known about the molecular mechanisms common to species from microbes to man, an argument can be made from biological facts that extends to non-random nutrient-dependent pheromone-controlled adaptive evolution. This biological-based argument can be compared to arguments that might be made to support a cosmological / mathematical argument for random mutations theory. Introduction: The epigenetic effects of nutrients on intracellular signaling and stochastic gene expression appear to enable adaptive evolution of tightly controlled organism-level thermoregulation in mammals. Nutrient-dependent single amino acid substitutions and de novo protein biosynthesis exemplify the involvement of the seemingly futile thermodynamic control of intracellular and intermolecular interactions in microbes that result in stochastic gene expression. Thermodynamically “futile” cycles of RNA transcription and degradation (Yap & Makeyev, 2013) may also be responsible for changes in pheromone production that enable accelerated changes in nutrient-dependent adaptive evolution controlled by the microRNA/messenger RNA (miRNA/mRNA) balance (see for review Meunier et al., 2013). Environmental cues, like those that signal the availability of glucose, appear to cause changes in the miRNA/mRNA balance that enable gene expression during developmental transitions required for successful nutrientdependent reproduction in species from microbes (Park et al., 2010) to man (Jobe, McQuate, &" @default.
- W1507147712 created "2016-06-24" @default.
- W1507147712 creator A5052880273 @default.
- W1507147712 date "2013-03-09" @default.
- W1507147712 modified "2023-09-23" @default.
- W1507147712 title "Nutrient-dependent / Pheromone–controlled thermodynamics and thermoregulation" @default.
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- W1507147712 doi "https://doi.org/10.6084/m9.figshare.643393.v1" @default.
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