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• W1507187164 abstract "Though dietary azuki bean (Vigna angularis) seed containing antioxidant proanthocyanidins was known to have multibiological activities including antioxidant, hypotensive, anti-inflammatory, and immunomodulatory activities, the antiangiogenic activity of ethanol extract of Vigna angularis (EVA) was never reported so far. In the present study, the antiangiogenic mechanism of EVA was examined in human umbilical vein endothelial cells (HUVECs). EVA showed weak cytotoxicity in HUVECs, while it significantly suppressed the VEGF induced proliferation of HUVECs. Consistently, wound healing assay revealed that EVA inhibited the VEGF induced migration of HUVECs. Also, EVA abrogated the VEGF induced tube formation of HUVECs in a concentration dependent fashion. Furthermore, Matrigel plug assay showed that EVA significantly reduced the hemoglobin level of Matrigel plug in mice compared to untreated control. Of note, EVA effectively attenuated the phosphorylation of VEGFR2, Erk, and Akt in VEGF-treated HUVECs. Overall, our findings suggest that EVA inhibits angiogenesis in VEGF-treated HUVECs via inhibition of phosphorylation of VEGFR2, ERK, and Akt." @default.
• W1507187164 created "2016-06-24" @default.
• W1507187164 creator A5018977246 @default.
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• W1507187164 date "2015-01-01" @default.
• W1507187164 modified "2023-10-09" @default.
• W1507187164 title "Antiangiogenic Effect of Ethanol Extract ofVigna angularisvia Inhibition of Phosphorylation of VEGFR2, Erk, and Akt" @default.
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• W1507187164 doi "https://doi.org/10.1155/2015/371368" @default.
• W1507187164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4556864" @default.
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• W1507187164 hasPublicationYear "2015" @default.
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