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- W1507207002 abstract "We report the use of β3 adrenergic receptor mediated activation of rat brain frontal cortex using mirabegron (a selective β3 adrenoceptor agonist), measured by 18F-FDG PET/CT. Another β3 agonist, CL 316,243, did not have this effect due to impermeability through the blood brain barrier (BBB), while atomoxetine, a norepinephrine transporter blocker, did increase 18F-FDG uptake in the frontal cortex. Mirabegron exhibited a dose-dependent increase in frontal cortex 18F-FDG uptake. These findings suggest a possible use of selective β3 adrenoceptor agonists in reversing regional glucose hypometabolism in the brain. Synapse 69:96–98, 2015. © 2014 Wiley Periodicals, Inc." @default.
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- W1507207002 date "2014-11-04" @default.
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- W1507207002 title "Enhancement of<sup>18</sup>F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist" @default.
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- W1507207002 doi "https://doi.org/10.1002/syn.21789" @default.
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