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• W1507316251 endingPage "269" @default.
• W1507316251 startingPage "262" @default.
• W1507316251 abstract "Immunoglobulin light chains are low molecular weight proteins that are filtered through the glomerulus and reabsorbed into the proximal tubular epithelium by binding initially to a heteromeric receptor complex composed of megalin and cubilin. Saturation of this receptor-mediated endocytotic process results in the presence of free light chains in the distal nephron and urine. In the course of metabolism of monoclonal light chains, nephrotoxicity can occur, resulting in clinical manifestations that can include acute kidney injury and progressive chronic kidney disease. Patterns of tubulopathic renal injury include proximal tubular epithelial cell cytotoxicity, tubulointerstitial nephritis and cast nephropathy (also known as 'myeloma kidney'). Research efforts over the past two decades have refined understanding of the molecular mechanisms involved in light chain-mediated tubular injury and are the subject of this review." @default.
• W1507316251 created "2016-06-24" @default.
• W1507316251 creator A5056020540 @default.
• W1507316251 date "2011-01-01" @default.
• W1507316251 modified "2023-09-29" @default.
• W1507316251 title "Light Chain-Mediated Tubulopathies" @default.
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• W1507316251 doi "https://doi.org/10.1159/000313959" @default.
• W1507316251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21252525" @default.
• W1507316251 hasPublicationYear "2011" @default.
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