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• W1507363724 abstract "The idea of has been a central organizing theme in contemporary biology, and Human Genome project and biotechnological advances have put in media spotlight. In this book Lenny Moss reconstructs history of concept, placing it in context of perennial interplay between theories of preformationism and theories of epigenesis. He finds that there are not one, but two, fundamental -- and fundamentally different -- senses of the gene in scientific use -- one heir to preformationism and other heir to epigenesis. Gene-P, preformationist concept, serves as an instrumental predictor of phenotypic outcomes, while Gene-D, of epigenesis, is a developmental resource that specifies possible amino acid sequences for proteins. Moss argues that popular idea that genes constitute blueprints for organisms is result of an unwarranted conflation of these independently valid senses of gene, and he analyzes rhetorical basis of this conflation.In heart of book, Moss uses Gene-D/Gene-P distinction to examine real basis of biological order and of pathological loss of order in cancer. He provides a detailed analysis of order-from-order role of cell membranes and compartmentalization and considers dynamic approaches to biological order such as that of Stuart Kauffman. He reviews history of cancer research with an emphasis on oncogene and tumor suppressor models and shows how these gene-centered strategies point back to significance of higher level, multi-cellular organizational fields in onset and progression of cancer. Finally, Moss draws on findings of Human Genome Project, biological modularity, and growing interest in resynthesyzing theories of evolution and development to look beyond century of gene toward a rebirth of biological understanding." @default.
• W1507363724 created "2016-06-24" @default.
• W1507363724 creator A5025639024 @default.
• W1507363724 date "2002-08-01" @default.
• W1507363724 modified "2023-09-27" @default.
• W1507363724 title "What Genes Can't Do" @default.
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