Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507366095> ?p ?o ?g. }
- W1507366095 endingPage "368" @default.
- W1507366095 startingPage "355" @default.
- W1507366095 abstract "This chapter investigates the role of the P2X7 receptor, formerly also known as P2Z, in microglia activation. The chapter presents the first evidence in support of the expression by microglial cells of an ATP-gated plasma membrane pore closely resembling the macrophage P2Z receptor. This was inferred on the basis of the ability of ATP to cause (1) fast plasma membrane depolarization, (2) uptake of ethidium bromide or lucifer yellow, and (3) release of cytoplasmic markers (e.g., lactate dehydrogenase), responses generally accepted as functional evidence for the expression of P2Z. This strong but indirect evidence was then confirmed by immunoblot analysis with an antiserum raised against the COOH tail of the P2X7 receptor that is in the meantime cloned from a rat brain library. A detailed investigation in the CNS gave no evidence for the presence of P2X7 in central neurons, thus suggesting that this receptor might have been originally cloned from microglia. The finding of a P2Z/P2X7 type receptor in microglia is consistent with the known peculiar expression of this molecule by immune cells and by mononuclear phagocytes." @default.
- W1507366095 created "2016-06-24" @default.
- W1507366095 creator A5017383986 @default.
- W1507366095 creator A5017854085 @default.
- W1507366095 creator A5040564157 @default.
- W1507366095 creator A5056313585 @default.
- W1507366095 date "1999-01-01" @default.
- W1507366095 modified "2023-09-26" @default.
- W1507366095 title "Chapter 29 The P2Z/P2X7 receptor of microglial cells: A novel immunomodulatory receptor" @default.
- W1507366095 cites W1488781666 @default.
- W1507366095 cites W1498022804 @default.
- W1507366095 cites W1533844265 @default.
- W1507366095 cites W1564075285 @default.
- W1507366095 cites W1578187871 @default.
- W1507366095 cites W1680053970 @default.
- W1507366095 cites W1926488431 @default.
- W1507366095 cites W1942214720 @default.
- W1507366095 cites W1970613983 @default.
- W1507366095 cites W1972952111 @default.
- W1507366095 cites W1991987508 @default.
- W1507366095 cites W1992484302 @default.
- W1507366095 cites W1996085928 @default.
- W1507366095 cites W1996421895 @default.
- W1507366095 cites W1999862704 @default.
- W1507366095 cites W2001979726 @default.
- W1507366095 cites W2002503549 @default.
- W1507366095 cites W2007301952 @default.
- W1507366095 cites W2009783162 @default.
- W1507366095 cites W2016357584 @default.
- W1507366095 cites W2018612932 @default.
- W1507366095 cites W2020764641 @default.
- W1507366095 cites W2021185580 @default.
- W1507366095 cites W2025500680 @default.
- W1507366095 cites W2028684902 @default.
- W1507366095 cites W2033177297 @default.
- W1507366095 cites W2038370680 @default.
- W1507366095 cites W2039933988 @default.
- W1507366095 cites W2043445250 @default.
- W1507366095 cites W2045680940 @default.
- W1507366095 cites W2051148897 @default.
- W1507366095 cites W2056351034 @default.
- W1507366095 cites W2056836891 @default.
- W1507366095 cites W2066784771 @default.
- W1507366095 cites W2076490210 @default.
- W1507366095 cites W2077418346 @default.
- W1507366095 cites W2085562484 @default.
- W1507366095 cites W2085678065 @default.
- W1507366095 cites W2085734938 @default.
- W1507366095 cites W2094803435 @default.
- W1507366095 cites W2104419986 @default.
- W1507366095 cites W2109759840 @default.
- W1507366095 cites W2136134177 @default.
- W1507366095 cites W2164116575 @default.
- W1507366095 cites W2171678969 @default.
- W1507366095 cites W2190292329 @default.
- W1507366095 cites W2323423108 @default.
- W1507366095 cites W2335571152 @default.
- W1507366095 cites W2403203704 @default.
- W1507366095 cites W4322697597 @default.
- W1507366095 cites W44963298 @default.
- W1507366095 doi "https://doi.org/10.1016/s0079-6123(08)63569-4" @default.
- W1507366095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10551011" @default.
- W1507366095 hasPublicationYear "1999" @default.
- W1507366095 type Work @default.
- W1507366095 sameAs 1507366095 @default.
- W1507366095 citedByCount "70" @default.
- W1507366095 countsByYear W15073660952012 @default.
- W1507366095 countsByYear W15073660952013 @default.
- W1507366095 countsByYear W15073660952015 @default.
- W1507366095 countsByYear W15073660952016 @default.
- W1507366095 countsByYear W15073660952017 @default.
- W1507366095 countsByYear W15073660952018 @default.
- W1507366095 countsByYear W15073660952019 @default.
- W1507366095 countsByYear W15073660952021 @default.
- W1507366095 countsByYear W15073660952023 @default.
- W1507366095 crossrefType "book-chapter" @default.
- W1507366095 hasAuthorship W1507366095A5017383986 @default.
- W1507366095 hasAuthorship W1507366095A5017854085 @default.
- W1507366095 hasAuthorship W1507366095A5040564157 @default.
- W1507366095 hasAuthorship W1507366095A5056313585 @default.
- W1507366095 hasConcept C153911025 @default.
- W1507366095 hasConcept C158157758 @default.
- W1507366095 hasConcept C170493617 @default.
- W1507366095 hasConcept C203014093 @default.
- W1507366095 hasConcept C2776914184 @default.
- W1507366095 hasConcept C2779486281 @default.
- W1507366095 hasConcept C2779830541 @default.
- W1507366095 hasConcept C55493867 @default.
- W1507366095 hasConcept C79879829 @default.
- W1507366095 hasConcept C86803240 @default.
- W1507366095 hasConcept C95444343 @default.
- W1507366095 hasConceptScore W1507366095C153911025 @default.
- W1507366095 hasConceptScore W1507366095C158157758 @default.
- W1507366095 hasConceptScore W1507366095C170493617 @default.
- W1507366095 hasConceptScore W1507366095C203014093 @default.
- W1507366095 hasConceptScore W1507366095C2776914184 @default.
- W1507366095 hasConceptScore W1507366095C2779486281 @default.
- W1507366095 hasConceptScore W1507366095C2779830541 @default.