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• W1507432827 abstract "After immunization with either live or heat-killed Salmonella typhimurium , mice responded with an extremely rapid production of bactericidal antibody which was correlated with the appearance of immunity to a heavy challenge dose (100 ld 50 ) of the virulent bacteria. Inactivation of sera with mercaptoethanol along with Sephadex fractionation indicated that the observed bactericidal activity was associated with a macroglobulin which was completely mercaptoethanol-sensitive. The unexpected finding, that a heat-killed vaccine gave excellent protection from a challenge dose which killed all unimmunized control mice, seriously challenges the theory attributing immunity against typhoid infection entirely to a cellular host factor produced only in response to a live vaccine." @default.
• W1507432827 created "2016-06-24" @default.
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• W1507432827 date "1967-03-01" @default.
• W1507432827 modified "2023-09-26" @default.
• W1507432827 title "Early Antibody Response in Mice to Either Infection or Immunization with Salmonella typhimurium" @default.
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• W1507432827 doi "https://doi.org/10.1128/jb.93.3.773-778.1967" @default.
• W1507432827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/276515" @default.
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