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• W1507536261 startingPage "1733" @default.
• W1507536261 abstract "Abstract The c-maf transcription factor is selectively expressed in IL-4-producing Th2 cells. It has been implicated in IL-4 gene transcription based on its ability to directly activate the IL-4 gene in nonexpressing B cells and to promote IL-4-induced Th2 differentiation. However, it has not been definitively shown that IL-4 production by other cells is dependent on the presence of c-maf. Here, we show that IL-4-producing mast cells do not express the c-maf factor. Furthermore, mutation of a defined c-maf binding site within the proximal IL-4 promoter, which profoundly affects transcription in T cells, has no effect on expression of a reporter gene driven by the IL-4 promoter in mast cells. These results demonstrate that c-maf and its target binding site are not required for IL-4 production in all cell types and delineate additional cis- and trans-acting elements that contribute to the cell-type specific transcriptional regulation of IL-4." @default.
• W1507536261 created "2016-06-24" @default.
• W1507536261 creator A5028310012 @default.
• W1507536261 creator A5045360268 @default.
• W1507536261 creator A5049373689 @default.
• W1507536261 date "1999-08-15" @default.
• W1507536261 modified "2023-10-14" @default.
• W1507536261 title "Cutting Edge: IL-4 Production by Mast Cells Does Not Require c-<i>maf</i>" @default.
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• W1507536261 doi "https://doi.org/10.4049/jimmunol.163.4.1733" @default.
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