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- W1507578049 abstract "Objective: To evaluate the changes in the number of Langerhans Cells (LC) observed in the epithelium of smokeless tobacco (SLT-induced) lesions. Methods: Microscopic sections from biopsies carried out in the buccal mucosa of twenty patients, who were chronic users of smokeless tobacco (SLT), were utilized. For the control group, twenty non-SLT users of SLT with normal mucosa were selected. The sections were studied with routine coloring and were immunostained for S-100, CD1a, Ki-67 and p63. These data were statistically analyzed by the Student’s t-test to investigate the differences in the expression of immune markers in normal mucosa and in SLT-induced leukoplakia lesions. Results: There was a significant difference in the immunolabeling of all markers between normal mucosa and SLT-induced lesions (p<0.001). The leukoplakia lesions in chronic SLT users demo strated a significant incr ase in th number of Langerha s cells and in the absenc of epithelial dyspla ia. Conclusion: The increase in the number of these cells represents the initial stag of leukoplakia. Ke words: Smokeless tobacco, leukoplakic lesions, cance , langerhans cells, chewing tobacc ." @default.
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- W1507578049 date "2013-01-01" @default.
- W1507578049 modified "2023-10-16" @default.
- W1507578049 title "Authors reply to “Comment on the Day-Care Surgery for Pilonidal Sinus Using Sinotomy Technique and Fibrin Glue Injection”" @default.
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- W1507578049 doi "https://doi.org/10.5455/aces.20130203024819" @default.
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