FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507582023> ?p ?o ?g. }

• W1507582023 abstract "Zinc deficiency is prevalent in low- and middle-income countries, and contributes to significant diarrhoea-, pneumonia-, and malaria-related morbidity and mortality among young children. Zinc deficiency also impairs growth.To assess the effects of zinc supplementation for preventing mortality and morbidity, and for promoting growth, in children aged six months to 12 years of age.Between December 2012 and January 2013, we searched CENTRAL, MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Embase, African Index Medicus, Conference Proceedings Citation Index, Dissertation Abstracts, Global Health, IndMED, LILACS, WHOLIS, metaRegister of Controlled Trials, and WHO ICTRP.Randomised controlled trials of preventive zinc supplementation in children aged six months to 12 years compared with no intervention, a placebo, or a waiting list control. We excluded hospitalised children and children with chronic diseases or conditions. We excluded food fortification or intake, sprinkles, and therapeutic interventions.Two authors screened studies, extracted data, and assessed risk of bias. We contacted trial authors for missing information.We included 80 randomised controlled trials with 205,401 eligible participants. We did not consider that the evidence for the key analyses of morbidity and mortality outcomes were affected by risk of bias. The risk ratio (RR) for all-cause mortality was compatible with a reduction and a small increased risk of death with zinc supplementation (RR 0.95, 95% confidence interval (CI) 0.86 to 1.05, 14 studies, high-quality evidence), and also for cause-specific mortality due to diarrhoea (RR 0.95, 95% CI 0.69 to 1.31, four studies, moderate-quality evidence), lower respiratory tract infection (LRTI) (RR 0.86, 95% CI 0.64 to 1.15, three studies, moderate-quality evidence), or malaria (RR 0.90, 95% CI 0.77 to 1.06, two studies, moderate-quality evidence).Supplementation reduced diarrhoea morbidity, including the incidence of all-cause diarrhoea (RR 0.87, 95% CI 0.85 to 0.89, 26 studies, moderate-quality evidence), but the results for LRTI and malaria were imprecise: LRTI (RR 1, 95% CI 0.94 to 1.07, 12 studies, moderate-quality evidence); malaria (RR 1.05, 95% 0.95 to 1.15, four studies, moderate-quality evidence).There was moderate-quality evidence of a very small improvement in height with supplementation (standardised mean difference (SMD) -0.09, 95% CI -0.13 to -0.06; 50 studies), but the size of this effect might not be clinically important. There was a medium to large positive effect on zinc status.Supplementation was associated with an increase in the number of participants with at least one vomiting episode (RR 1.29, 95% CI 1.14 to 1.46, five studies, high-quality evidence). We found no clear evidence of benefit or harm of supplementation with regard to haemoglobin or iron status. Supplementation had a negative effect on copper status.In our opinion, the benefits of preventive zinc supplementation outweigh the harms in areas where the risk of zinc deficiency is relatively high. Further research should determine optimal intervention characteristics such as supplement dose." @default.
• W1507582023 created "2016-06-24" @default.
• W1507582023 creator A5011297642 @default.
• W1507582023 creator A5028823184 @default.
• W1507582023 creator A5031009188 @default.
• W1507582023 creator A5031885445 @default.
• W1507582023 creator A5043540834 @default.
• W1507582023 creator A5055917772 @default.
• W1507582023 creator A5070322394 @default.
• W1507582023 creator A5071277873 @default.
• W1507582023 date "2014-05-15" @default.
• W1507582023 modified "2023-10-01" @default.
• W1507582023 title "Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age" @default.
• W1507582023 cites W114340524 @default.
• W1507582023 cites W1480070242 @default.
• W1507582023 cites W1502094105 @default.
• W1507582023 cites W1558260734 @default.
• W1507582023 cites W1561055920 @default.
• W1507582023 cites W1562115222 @default.
• W1507582023 cites W1792089395 @default.
• W1507582023 cites W1798252362 @default.
• W1507582023 cites W1812189305 @default.
• W1507582023 cites W1813760287 @default.
• W1507582023 cites W1846260220 @default.
• W1507582023 cites W1880884476 @default.
• W1507582023 cites W1884870579 @default.
• W1507582023 cites W1898638886 @default.
• W1507582023 cites W1901926538 @default.
• W1507582023 cites W1902451973 @default.
• W1507582023 cites W1904307752 @default.
• W1507582023 cites W1924785257 @default.
• W1507582023 cites W1925179537 @default.
• W1507582023 cites W1938461180 @default.
• W1507582023 cites W1940973873 @default.
• W1507582023 cites W1942860958 @default.
• W1507582023 cites W1943607432 @default.
• W1507582023 cites W1943892906 @default.
• W1507582023 cites W1951636062 @default.
• W1507582023 cites W1953299051 @default.
• W1507582023 cites W1960324916 @default.
• W1507582023 cites W1961197797 @default.
• W1507582023 cites W1965945511 @default.
• W1507582023 cites W1968004758 @default.
• W1507582023 cites W1970577749 @default.
• W1507582023 cites W1973470751 @default.
• W1507582023 cites W1974667168 @default.
• W1507582023 cites W1975349420 @default.
• W1507582023 cites W1976639739 @default.
• W1507582023 cites W1977847430 @default.
• W1507582023 cites W1981001019 @default.
• W1507582023 cites W1981680557 @default.
• W1507582023 cites W1983422919 @default.
• W1507582023 cites W1984513006 @default.
• W1507582023 cites W1986139763 @default.
• W1507582023 cites W1991612267 @default.
• W1507582023 cites W1993140967 @default.
• W1507582023 cites W1994017216 @default.
• W1507582023 cites W1994512656 @default.
• W1507582023 cites W1997457574 @default.
• W1507582023 cites W1998771728 @default.
• W1507582023 cites W2000795003 @default.
• W1507582023 cites W2003617573 @default.
• W1507582023 cites W2004327240 @default.
• W1507582023 cites W2004542762 @default.
• W1507582023 cites W2006501689 @default.
• W1507582023 cites W2010234301 @default.
• W1507582023 cites W2010611842 @default.
• W1507582023 cites W2014377847 @default.
• W1507582023 cites W2014533281 @default.
• W1507582023 cites W2017677127 @default.
• W1507582023 cites W2018682562 @default.
• W1507582023 cites W2019007971 @default.
• W1507582023 cites W2020112113 @default.
• W1507582023 cites W2021002667 @default.
• W1507582023 cites W2021303561 @default.
• W1507582023 cites W2023047568 @default.
• W1507582023 cites W2025195899 @default.
• W1507582023 cites W2025583642 @default.
• W1507582023 cites W2028047084 @default.
• W1507582023 cites W2028863447 @default.
• W1507582023 cites W2030254767 @default.
• W1507582023 cites W2031131502 @default.
• W1507582023 cites W2033747645 @default.
• W1507582023 cites W2035619882 @default.
• W1507582023 cites W2035799929 @default.
• W1507582023 cites W2039226591 @default.
• W1507582023 cites W2040741743 @default.
• W1507582023 cites W2040758189 @default.
• W1507582023 cites W2044972237 @default.
• W1507582023 cites W2048504899 @default.
• W1507582023 cites W2050086235 @default.
• W1507582023 cites W2051504696 @default.
• W1507582023 cites W2053624874 @default.
• W1507582023 cites W2055970752 @default.
• W1507582023 cites W2056521158 @default.
• W1507582023 cites W2057765694 @default.
• W1507582023 cites W2059783243 @default.
• W1507582023 cites W2061239652 @default.
• W1507582023 cites W2062049318 @default.
• W1507582023 cites W2062765507 @default.

• next