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- W1507700987 endingPage "1004" @default.
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- W1507700987 abstract "The largest subunit of RNA polymerase II, Rpb1, contains an unusual C-terminal domain (CTD) composed of numerous repeats of the YSPTSPS consensus sequence. This sequence is the target of post-translational modifications such as phosphorylation, glycosylation, methylation and transitions between stereoisomeric states, resulting in a vast combinatorial potential referred to as the CTD code. In order to gain insight into the biological significance of this code, several studies recently reported the genome-wide distribution of some of these modified polymerases and associated factors in either fission yeast (Schizosaccharomyces pombe) or budding yeast (Saccharomyces cerevisiae). The resulting occupancy maps reveal that a general RNA polymerase II transcription complex exists and undergoes uniform transitions from initiation to elongation to termination. Nevertheless, CTD phosphorylation dynamics result in a gene-specific effect on mRNA expression. In this review, we focus on the gene-specific requirement of CTD phosphorylation and discuss in more detail the case of serine 2 phosphorylation (S2P) within the CTD, a modification that is dispensable for general transcription in fission yeast but strongly affects transcription reprogramming and cell differentiation in response to environmental cues. The recent discovery of Cdk12 as a genuine CTD S2 kinase and its requirement for gene-specific expression are discussed in the wider context of metazoa." @default.
- W1507700987 created "2016-06-24" @default.
- W1507700987 creator A5030942322 @default.
- W1507700987 creator A5079472126 @default.
- W1507700987 date "2012-05-04" @default.
- W1507700987 modified "2023-09-23" @default.
- W1507700987 title "Gene-specific requirement of RNA polymerase II CTD phosphorylation" @default.
- W1507700987 cites W1481179850 @default.
- W1507700987 cites W1545169951 @default.
- W1507700987 cites W1954289976 @default.
- W1507700987 cites W1963532124 @default.
- W1507700987 cites W1966695149 @default.
- W1507700987 cites W1970933479 @default.
- W1507700987 cites W1979040744 @default.
- W1507700987 cites W1981930838 @default.
- W1507700987 cites W1982003542 @default.
- W1507700987 cites W1982790679 @default.
- W1507700987 cites W1983496172 @default.
- W1507700987 cites W1986421128 @default.
- W1507700987 cites W1987169965 @default.
- W1507700987 cites W1989329472 @default.
- W1507700987 cites W1994485628 @default.
- W1507700987 cites W2004408181 @default.
- W1507700987 cites W2006215395 @default.
- W1507700987 cites W2009444548 @default.
- W1507700987 cites W2010781201 @default.
- W1507700987 cites W2011542817 @default.
- W1507700987 cites W2011808534 @default.
- W1507700987 cites W2013286714 @default.
- W1507700987 cites W2013535834 @default.
- W1507700987 cites W2018071392 @default.
- W1507700987 cites W2019246380 @default.
- W1507700987 cites W2028096667 @default.
- W1507700987 cites W2028304990 @default.
- W1507700987 cites W2032446389 @default.
- W1507700987 cites W2032742580 @default.
- W1507700987 cites W2034185087 @default.
- W1507700987 cites W2035225194 @default.
- W1507700987 cites W2037237823 @default.
- W1507700987 cites W2042368221 @default.
- W1507700987 cites W2045755743 @default.
- W1507700987 cites W2045766250 @default.
- W1507700987 cites W2045959839 @default.
- W1507700987 cites W2046336423 @default.
- W1507700987 cites W2049017158 @default.
- W1507700987 cites W2049858249 @default.
- W1507700987 cites W2051231585 @default.
- W1507700987 cites W2054084236 @default.
- W1507700987 cites W2056304859 @default.
- W1507700987 cites W2058262378 @default.
- W1507700987 cites W2058565051 @default.
- W1507700987 cites W2059362435 @default.
- W1507700987 cites W2060554618 @default.
- W1507700987 cites W2065029409 @default.
- W1507700987 cites W2067455706 @default.
- W1507700987 cites W2067584429 @default.
- W1507700987 cites W2068750645 @default.
- W1507700987 cites W2071177849 @default.
- W1507700987 cites W2071837083 @default.
- W1507700987 cites W2072836045 @default.
- W1507700987 cites W2074661080 @default.
- W1507700987 cites W2074812841 @default.
- W1507700987 cites W2080365558 @default.
- W1507700987 cites W2081322742 @default.
- W1507700987 cites W2085574038 @default.
- W1507700987 cites W2085853194 @default.
- W1507700987 cites W2087732988 @default.
- W1507700987 cites W2088343433 @default.
- W1507700987 cites W2088389307 @default.
- W1507700987 cites W2091107314 @default.
- W1507700987 cites W2097621806 @default.
- W1507700987 cites W2100649212 @default.
- W1507700987 cites W2101359917 @default.
- W1507700987 cites W2101424708 @default.
- W1507700987 cites W2104531065 @default.
- W1507700987 cites W2107635128 @default.
- W1507700987 cites W2111646262 @default.
- W1507700987 cites W2116887390 @default.
- W1507700987 cites W2117800899 @default.
- W1507700987 cites W2118688916 @default.
- W1507700987 cites W2119024534 @default.
- W1507700987 cites W2121649903 @default.
- W1507700987 cites W2123603532 @default.
- W1507700987 cites W2123814549 @default.
- W1507700987 cites W2126370137 @default.
- W1507700987 cites W2132760358 @default.
- W1507700987 cites W2134618983 @default.
- W1507700987 cites W2135869142 @default.
- W1507700987 cites W2137001129 @default.
- W1507700987 cites W2137647744 @default.
- W1507700987 cites W2138113682 @default.
- W1507700987 cites W2139910083 @default.
- W1507700987 cites W2143395788 @default.
- W1507700987 cites W2148917483 @default.
- W1507700987 cites W2149855651 @default.
- W1507700987 cites W2151298550 @default.
- W1507700987 cites W2155820845 @default.
- W1507700987 cites W2156566553 @default.