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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507722433> ?p ?o ?g. }

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• W1507722433 abstract "We report SAR studies on a novel non-peptidic somatostatin receptor 3 (SSTR3) agonist lead series derived from (4-phenyl-1H-imidazol-2-yl)methanamine. This effort led to the discovery of a highly potent low molecular weight SSTR3 agonist 5c (EC50 = 5.2 nM, MW = 359). The results from molecular overlays of 5c onto the L-129 structure indicate good alignment, and two main differences of the proposed overlays of the antagonist MK-4256 onto the conformation of 5c lead to inversion of antagonism to agonism." @default.
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• W1507722433 date "2015-09-01" @default.
• W1507722433 modified "2023-09-23" @default.
• W1507722433 title "Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists" @default.
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• W1507722433 doi "https://doi.org/10.1016/j.bmcl.2015.06.087" @default.
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