FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507743852> ?p ?o ?g. }

• W1507743852 endingPage "4614" @default.
• W1507743852 startingPage "4601" @default.
• W1507743852 abstract "Extraocular muscle is fundamentally distinct from other skeletal muscle and demonstrates specific anatomical divisions, unique innervation, diverse myosin isoform expression patterns, a distinct genomic profile and differential involvement in neuromuscular disorders. The paired-like homeodomain transcription factor 2 (Pitx2) is known to regulate the formation of extraocular muscle development and in this report we show that its expression in adulthood also defines certain extraocular muscle traits. We found that expression of slow-MyHC and slow-tonic MyHC, along with contractile regulatory proteins troponin I and troponin T, is reduced during the first 3 weeks after birth in mice with conditional knockout of Pitx2, designated Pitx2(Δflox/Δflox). En grappe endplates, which are normally only found on slow-MyHC expressing fibres, were not identified in the Pitx2(Δflox/Δflox) extraocular muscle, suggesting that altered innervation was responsible for the loss in slow-MyHC expression. Extraocular muscle (EOM)-specific MyHC expressing fibres were dramatically reduced at P14 and rarely detected at 3 months in the Pitx2(Δflox/Δflox) mice. 2A-MyHC fibres, which are excluded from mid-belly region in wild-type mice, dominated the orbital layer with no apparent longitudinal variation in the Pitx2(Δflox/Δflox) mice. Pure 2X-MyHC fibres, only present at distal ends in the wild-type mice, populated the outer global layer in the mid-belly region of the Pitx2(Δflox/Δflox) mice. Pitx2 influences slow-MyHC, slow-tonic MyHC and EOM-MyHC expression in extraocular muscle and its absence leads to increased expression of 2X-MyHC and 2A-MyHC. Precise definition of the regulation of MyHC isoforms in extraocular muscle may allow their rational manipulation, in order to alter muscle contractility for therapeutic purposes." @default.
• W1507743852 created "2016-06-24" @default.
• W1507743852 creator A5006012404 @default.
• W1507743852 creator A5068116120 @default.
• W1507743852 creator A5085950278 @default.
• W1507743852 date "2011-09-01" @default.
• W1507743852 modified "2023-10-18" @default.
• W1507743852 title "Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle" @default.
• W1507743852 cites W1486113765 @default.
• W1507743852 cites W1498886216 @default.
• W1507743852 cites W1518173022 @default.
• W1507743852 cites W1539345324 @default.
• W1507743852 cites W1577750487 @default.
• W1507743852 cites W1674167019 @default.
• W1507743852 cites W1959862498 @default.
• W1507743852 cites W1963590825 @default.
• W1507743852 cites W1971380067 @default.
• W1507743852 cites W1975578266 @default.
• W1507743852 cites W1977317296 @default.
• W1507743852 cites W1983350277 @default.
• W1507743852 cites W1986599189 @default.
• W1507743852 cites W1988557430 @default.
• W1507743852 cites W1991923623 @default.
• W1507743852 cites W1995352401 @default.
• W1507743852 cites W2000044719 @default.
• W1507743852 cites W2011903881 @default.
• W1507743852 cites W2020890552 @default.
• W1507743852 cites W2032363591 @default.
• W1507743852 cites W2044872925 @default.
• W1507743852 cites W2046993766 @default.
• W1507743852 cites W2053407799 @default.
• W1507743852 cites W2060575360 @default.
• W1507743852 cites W2069265939 @default.
• W1507743852 cites W2071745519 @default.
• W1507743852 cites W2078660921 @default.
• W1507743852 cites W2088927533 @default.
• W1507743852 cites W2092076387 @default.
• W1507743852 cites W2121999840 @default.
• W1507743852 cites W2132872450 @default.
• W1507743852 cites W2138321124 @default.
• W1507743852 cites W2143076670 @default.
• W1507743852 cites W2252540329 @default.
• W1507743852 cites W2343099077 @default.
• W1507743852 cites W33534653 @default.
• W1507743852 doi "https://doi.org/10.1113/jphysiol.2011.207076" @default.
• W1507743852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3208227" @default.
• W1507743852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21727215" @default.
• W1507743852 hasPublicationYear "2011" @default.
• W1507743852 type Work @default.
• W1507743852 sameAs 1507743852 @default.
• W1507743852 citedByCount "24" @default.
• W1507743852 countsByYear W15077438522012 @default.
• W1507743852 countsByYear W15077438522013 @default.
• W1507743852 countsByYear W15077438522014 @default.
• W1507743852 countsByYear W15077438522015 @default.
• W1507743852 countsByYear W15077438522017 @default.
• W1507743852 countsByYear W15077438522019 @default.
• W1507743852 countsByYear W15077438522020 @default.
• W1507743852 countsByYear W15077438522021 @default.
• W1507743852 countsByYear W15077438522022 @default.
• W1507743852 crossrefType "journal-article" @default.
• W1507743852 hasAuthorship W1507743852A5006012404 @default.
• W1507743852 hasAuthorship W1507743852A5068116120 @default.
• W1507743852 hasAuthorship W1507743852A5085950278 @default.
• W1507743852 hasBestOaLocation W15077438522 @default.
• W1507743852 hasConcept C104317684 @default.
• W1507743852 hasConcept C105702510 @default.
• W1507743852 hasConcept C121587040 @default.
• W1507743852 hasConcept C126322002 @default.
• W1507743852 hasConcept C127573956 @default.
• W1507743852 hasConcept C134018914 @default.
• W1507743852 hasConcept C150194340 @default.
• W1507743852 hasConcept C2776807875 @default.
• W1507743852 hasConcept C53345823 @default.
• W1507743852 hasConcept C54355233 @default.
• W1507743852 hasConcept C6997183 @default.
• W1507743852 hasConcept C71924100 @default.
• W1507743852 hasConcept C86803240 @default.
• W1507743852 hasConcept C90620890 @default.
• W1507743852 hasConcept C95444343 @default.
• W1507743852 hasConceptScore W1507743852C104317684 @default.
• W1507743852 hasConceptScore W1507743852C105702510 @default.
• W1507743852 hasConceptScore W1507743852C121587040 @default.
• W1507743852 hasConceptScore W1507743852C126322002 @default.
• W1507743852 hasConceptScore W1507743852C127573956 @default.
• W1507743852 hasConceptScore W1507743852C134018914 @default.
• W1507743852 hasConceptScore W1507743852C150194340 @default.
• W1507743852 hasConceptScore W1507743852C2776807875 @default.
• W1507743852 hasConceptScore W1507743852C53345823 @default.
• W1507743852 hasConceptScore W1507743852C54355233 @default.
• W1507743852 hasConceptScore W1507743852C6997183 @default.
• W1507743852 hasConceptScore W1507743852C71924100 @default.
• W1507743852 hasConceptScore W1507743852C86803240 @default.
• W1507743852 hasConceptScore W1507743852C90620890 @default.
• W1507743852 hasConceptScore W1507743852C95444343 @default.
• W1507743852 hasIssue "18" @default.
• W1507743852 hasLocation W15077438521 @default.
• W1507743852 hasLocation W15077438522 @default.

• next