FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507789199> ?p ?o ?g. }

• W1507789199 endingPage "14100" @default.
• W1507789199 startingPage "14094" @default.
• W1507789199 abstract "Cultured skin fibroblasts from a proband with an autosomal dominant variant of osteogenesis inperfecta were found to synthesize approximately equal amounts of normal pro-alpha 2(I) chains of type I procollagen and pro-alpha 2(I) chains which migrated more rapidly when examined by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. The structural alteration was present in alpha 2(I)-CB4, a cyanogen bromide fragment containing amino acid residues 7-327 of the alpha 2 chain, and it appeared to be a deletion of about 30 amino acids. The pro-alpha 2(I) chains with the apparent deletion associated with normal pro-alpha 1(I) chains synthesized by the same fibroblasts and formed triple-helical type I procollagen. The presence of the altered pro-alpha 2 chains in trimers of procollagen had two consequences in terms of the physical properties of the molecule. One was to decrease the thermal stability of the protein as judged by resistance to proteolysis at 37 degrees C and by the helix to coil transition as assayed by circular dichroism. The second consequence was to make type I procollagen containing the shortened pro-alpha 2(I) chains resistant to digestion by procollagen N-proteinase. The simplest explanation for the data is that the apparent deletion in half the pro-alpha 2(I) chains produced a partial unfolding of the N-terminal region of type I procollagen which prevented processing of the protein by procollagen N-proteinase." @default.
• W1507789199 created "2016-06-24" @default.
• W1507789199 creator A5030828941 @default.
• W1507789199 creator A5073685961 @default.
• W1507789199 creator A5077455086 @default.
• W1507789199 date "1984-11-01" @default.
• W1507789199 modified "2023-09-27" @default.
• W1507789199 title "A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase." @default.
• W1507789199 cites W1513604840 @default.
• W1507789199 cites W1524486180 @default.
• W1507789199 cites W1526243437 @default.
• W1507789199 cites W1527633762 @default.
• W1507789199 cites W1602552977 @default.
• W1507789199 cites W1978987630 @default.
• W1507789199 cites W1982782860 @default.
• W1507789199 cites W1994764794 @default.
• W1507789199 cites W2015807660 @default.
• W1507789199 cites W2033034806 @default.
• W1507789199 cites W2035145613 @default.
• W1507789199 cites W2037811047 @default.
• W1507789199 cites W2039030416 @default.
• W1507789199 cites W2045676793 @default.
• W1507789199 cites W2048615756 @default.
• W1507789199 cites W2056522916 @default.
• W1507789199 cites W2074974653 @default.
• W1507789199 cites W2083453910 @default.
• W1507789199 cites W2090238172 @default.
• W1507789199 cites W2090885889 @default.
• W1507789199 cites W2098828493 @default.
• W1507789199 cites W2110795940 @default.
• W1507789199 cites W2142638949 @default.
• W1507789199 cites W2145346213 @default.
• W1507789199 cites W2158400950 @default.
• W1507789199 cites W2259592571 @default.
• W1507789199 cites W2765256144 @default.
• W1507789199 doi "https://doi.org/10.1016/s0021-9258(18)89861-1" @default.
• W1507789199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6438090" @default.
• W1507789199 hasPublicationYear "1984" @default.
• W1507789199 type Work @default.
• W1507789199 sameAs 1507789199 @default.
• W1507789199 citedByCount "61" @default.
• W1507789199 countsByYear W15077891992014 @default.
• W1507789199 crossrefType "journal-article" @default.
• W1507789199 hasAuthorship W1507789199A5030828941 @default.
• W1507789199 hasAuthorship W1507789199A5073685961 @default.
• W1507789199 hasAuthorship W1507789199A5077455086 @default.
• W1507789199 hasBestOaLocation W15077891991 @default.
• W1507789199 hasConcept C104317684 @default.
• W1507789199 hasConcept C105702510 @default.
• W1507789199 hasConcept C134018914 @default.
• W1507789199 hasConcept C135763542 @default.
• W1507789199 hasConcept C141071460 @default.
• W1507789199 hasConcept C153471976 @default.
• W1507789199 hasConcept C178790620 @default.
• W1507789199 hasConcept C185592680 @default.
• W1507789199 hasConcept C2775944032 @default.
• W1507789199 hasConcept C2777668750 @default.
• W1507789199 hasConcept C49453240 @default.
• W1507789199 hasConcept C55493867 @default.
• W1507789199 hasConcept C59061564 @default.
• W1507789199 hasConcept C64348721 @default.
• W1507789199 hasConcept C64943373 @default.
• W1507789199 hasConcept C71924100 @default.
• W1507789199 hasConcept C86803240 @default.
• W1507789199 hasConceptScore W1507789199C104317684 @default.
• W1507789199 hasConceptScore W1507789199C105702510 @default.
• W1507789199 hasConceptScore W1507789199C134018914 @default.
• W1507789199 hasConceptScore W1507789199C135763542 @default.
• W1507789199 hasConceptScore W1507789199C141071460 @default.
• W1507789199 hasConceptScore W1507789199C153471976 @default.
• W1507789199 hasConceptScore W1507789199C178790620 @default.
• W1507789199 hasConceptScore W1507789199C185592680 @default.
• W1507789199 hasConceptScore W1507789199C2775944032 @default.
• W1507789199 hasConceptScore W1507789199C2777668750 @default.
• W1507789199 hasConceptScore W1507789199C49453240 @default.
• W1507789199 hasConceptScore W1507789199C55493867 @default.
• W1507789199 hasConceptScore W1507789199C59061564 @default.
• W1507789199 hasConceptScore W1507789199C64348721 @default.
• W1507789199 hasConceptScore W1507789199C64943373 @default.
• W1507789199 hasConceptScore W1507789199C71924100 @default.
• W1507789199 hasConceptScore W1507789199C86803240 @default.
• W1507789199 hasIssue "22" @default.
• W1507789199 hasLocation W15077891991 @default.
• W1507789199 hasOpenAccess W1507789199 @default.
• W1507789199 hasPrimaryLocation W15077891991 @default.
• W1507789199 hasRelatedWork W1507789199 @default.
• W1507789199 hasRelatedWork W1976818385 @default.
• W1507789199 hasRelatedWork W1990838861 @default.
• W1507789199 hasRelatedWork W2053779192 @default.
• W1507789199 hasRelatedWork W2073144710 @default.
• W1507789199 hasRelatedWork W2110795940 @default.
• W1507789199 hasRelatedWork W2152506486 @default.
• W1507789199 hasRelatedWork W2272538517 @default.
• W1507789199 hasRelatedWork W2748952813 @default.
• W1507789199 hasRelatedWork W4295905646 @default.
• W1507789199 hasVolume "259" @default.
• W1507789199 isParatext "false" @default.
• W1507789199 isRetracted "false" @default.

• next