Matches in SemOpenAlex for { <https://semopenalex.org/work/W1507822951> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1507822951 abstract "This thesis investigates the use of manual measures of brain structure delineation on MR scans in order to assess atrophy in dementia. It further investigates the automation of atrophy measures. A new protocol for outlining the cingulate is described and was applied to groups of Alzheimer's disease (AD) and control subjects. The application of existing hippocampal and amygdala protocols to a group of pathologically-confirmed AD, frontotemporal lobar degeneration (FTLD) and controls is detailed. This analysis shows cross-sectional measurements were useful subject-group discriminators and that patterns of atrophy within and between structures may distinguish diseases. Manual delineation of regions (cingulate and hippocampus) was extended to longitudinal studies to establish atrophy rates in groups of AD, FTLD and controls. The cingulate was shown to be at least as affected as the hippocampus by disease. Hippocampal atrophy rates from inter-scan intervals of six months were compared with measurements in the same subjects of one-year intervals. Results from studies combining cross-sectional and longitudinal hippocampal data are described. These assess the asymmetry of the structure and investigate the pre-symptomatic decrease in volume in familial AD subjects. Semi-automated techniques were performed which utilise registration of serial hippocampi to assess change longitudinally. Results show the semi-automated techniques to be reliable and consistent with manual measures. These techniques were then applied to scans from a multi-centre clinical trial and again consistency with manual measures was assessed. The generation of fully-automated template-based hippocampal segmentations is described. The approximate regions generated from the template were used to quantify the boundary shift integral and the resultant atrophy rates were compared with manual rates revealing automated measures to be consistent with manual measures. These results are put within the context of other similar studies by performing a meta analysis of hippocampal atrophy rates. Implications for diagnosis and monitoring disease progression are discussed." @default.
- W1507822951 created "2016-06-24" @default.
- W1507822951 creator A5007836718 @default.
- W1507822951 date "2007-01-01" @default.
- W1507822951 modified "2023-09-26" @default.
- W1507822951 title "MRI-based measures in Alzheimer's disease and related disorders." @default.
- W1507822951 hasPublicationYear "2007" @default.
- W1507822951 type Work @default.
- W1507822951 sameAs 1507822951 @default.
- W1507822951 citedByCount "0" @default.
- W1507822951 crossrefType "dissertation" @default.
- W1507822951 hasAuthorship W1507822951A5007836718 @default.
- W1507822951 hasConcept C142724271 @default.
- W1507822951 hasConcept C148762608 @default.
- W1507822951 hasConcept C15744967 @default.
- W1507822951 hasConcept C169760540 @default.
- W1507822951 hasConcept C169900460 @default.
- W1507822951 hasConcept C2776939681 @default.
- W1507822951 hasConcept C2778641062 @default.
- W1507822951 hasConcept C2778733324 @default.
- W1507822951 hasConcept C2779134260 @default.
- W1507822951 hasConcept C2779483572 @default.
- W1507822951 hasConcept C2780715579 @default.
- W1507822951 hasConcept C2780906993 @default.
- W1507822951 hasConcept C2781161787 @default.
- W1507822951 hasConcept C2781172350 @default.
- W1507822951 hasConcept C502032728 @default.
- W1507822951 hasConcept C71924100 @default.
- W1507822951 hasConceptScore W1507822951C142724271 @default.
- W1507822951 hasConceptScore W1507822951C148762608 @default.
- W1507822951 hasConceptScore W1507822951C15744967 @default.
- W1507822951 hasConceptScore W1507822951C169760540 @default.
- W1507822951 hasConceptScore W1507822951C169900460 @default.
- W1507822951 hasConceptScore W1507822951C2776939681 @default.
- W1507822951 hasConceptScore W1507822951C2778641062 @default.
- W1507822951 hasConceptScore W1507822951C2778733324 @default.
- W1507822951 hasConceptScore W1507822951C2779134260 @default.
- W1507822951 hasConceptScore W1507822951C2779483572 @default.
- W1507822951 hasConceptScore W1507822951C2780715579 @default.
- W1507822951 hasConceptScore W1507822951C2780906993 @default.
- W1507822951 hasConceptScore W1507822951C2781161787 @default.
- W1507822951 hasConceptScore W1507822951C2781172350 @default.
- W1507822951 hasConceptScore W1507822951C502032728 @default.
- W1507822951 hasConceptScore W1507822951C71924100 @default.
- W1507822951 hasLocation W15078229511 @default.
- W1507822951 hasOpenAccess W1507822951 @default.
- W1507822951 hasPrimaryLocation W15078229511 @default.
- W1507822951 hasRelatedWork W1550362224 @default.
- W1507822951 hasRelatedWork W1756674874 @default.
- W1507822951 hasRelatedWork W1981789870 @default.
- W1507822951 hasRelatedWork W2010128607 @default.
- W1507822951 hasRelatedWork W2023916538 @default.
- W1507822951 hasRelatedWork W2062383826 @default.
- W1507822951 hasRelatedWork W2087159877 @default.
- W1507822951 hasRelatedWork W2093092963 @default.
- W1507822951 hasRelatedWork W2111913931 @default.
- W1507822951 hasRelatedWork W2122632052 @default.
- W1507822951 hasRelatedWork W2124763288 @default.
- W1507822951 hasRelatedWork W2127117802 @default.
- W1507822951 hasRelatedWork W2148601182 @default.
- W1507822951 hasRelatedWork W2346768366 @default.
- W1507822951 hasRelatedWork W2487103609 @default.
- W1507822951 hasRelatedWork W2586141179 @default.
- W1507822951 hasRelatedWork W2804353669 @default.
- W1507822951 hasRelatedWork W2955634112 @default.
- W1507822951 hasRelatedWork W3132579798 @default.
- W1507822951 hasRelatedWork W3154727209 @default.
- W1507822951 isParatext "false" @default.
- W1507822951 isRetracted "false" @default.
- W1507822951 magId "1507822951" @default.
- W1507822951 workType "dissertation" @default.