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• W1507865998 abstract "Abstract Aim The aim of this study was to investigate the impact of interpregnancy interval as a risk factor on multiple adverse perinatal outcomes. Material and Methods Interpregnancy intervals and confounding factors were determined for healthy pregnancies (controls [ n = 357]) and for pregnancies complicated by adverse perinatal outcomes. Interpregnancy interval was categorized as <6, 6–11, 12–17, 18–23, 24–35 and ≥36 months. Adverse outcomes included spontaneous labor leading to preterm birth ( n = 265), preterm premature rupture of membranes ( n = 245), pre‐eclampsia ( n = 286), gestational diabetes ( n = 302), abnormal placentation ( n = 154), anemia ( n = 314), congenital anomalies ( n = 459), post‐partum hemorrhage ( n = 326) and small for gestational age ( n = 168). Multivariate logistic regression analysis was performed to assess the association of each outcome with the interpregnancy interval categories. Results Spontaneous labor leading to preterm birth (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.13–1.97), preterm premature rupture of membranes (OR, 1.69; 95%CI, 1.28–2.39), congenital anomalies (OR, 1.38; 95%CI, 1.09–1.76) and small for gestational age (OR, 1.68; 95%CI, 1.14–2.34) were significantly associated with intervals of <6 months. Among congenital anomalies, short interpregnancy interval represents an increased risk for cardiac defects (OR, 1.55; 95%CI, 1.09–5.46), neural tube defects (OR, 2.06; 95%CI, 1.32–7.64) and central nervous system anomalies (OR, 1.45; 95%CI, 1.12–3.65). Conclusion Short interpregnancy interval is an independent risk factor for adverse perinatal outcomes." @default.
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• W1507865998 date "2015-07-14" @default.
• W1507865998 modified "2023-10-03" @default.
• W1507865998 title "Impact of interpregnancy interval on the subsequent risk of adverse perinatal outcomes" @default.
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• W1507865998 doi "https://doi.org/10.1111/jog.12783" @default.
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