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• W1507890231 abstract "We have investigated the mechanism by which dexamethasone (DEX) increases alpha-fetoprotein (AFP) secretion by the McA-RH8994 rat hepatoma cell line. In contrast to the 7777 cell line, DEX was found to increase the amount of hybridizable cytoplasmic AFP mRNA in McA-RH8994 cells. This effect was dose-dependent, reversible after removal of DEX, and was partially blocked by progesterone in excess, indicating a receptor-mediated response. In vitro nuclear transcription experiments showed that DEX increased AFP gene transcription in McA-RH8994 cells. Cycloheximide blocked the effect of DEX on AFP mRNA levels in both the McA-RH8994 and 7777 cell lines, showing that ongoing protein synthesis is required for glucocorticoids either to enhance or to suppress AFP gene expression in these cell lines." @default.
• W1507890231 created "2016-06-24" @default.
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• W1507890231 creator A5084391691 @default.
• W1507890231 date "1986-04-01" @default.
• W1507890231 modified "2023-09-27" @default.
• W1507890231 title "Mechanism of the dexamethasone effect on alpha-fetoprotein gene expression in McA-RH8994 rat hepatoma cells." @default.
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• W1507890231 doi "https://doi.org/10.1016/s0021-9258(17)38553-8" @default.
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• W1507890231 hasPublicationYear "1986" @default.
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