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- W1507899139 abstract "BALB/c (H-2d) thymus-derived lymphocytes sensitized to C57BL/6 (H-2b) alloantigens have been propagated in vitro for over 9 months. These T lymphocytes are specifically cytotoxic to H-2b target cells but are stimulated to proliferate by both H-2b and H-2k spleen cells. This indicates that for these selected cells the antigen requirements for cell proliferation are different from those for cell-mediated cytotoxicity. If not continuously stimulated with allogeneic spleen cells, the cytotoxic cultures fail to divide and rapidly lose their cytotoxic activity. Allogeneic erythrocytes do not stimulate cell proliferation in quiescent cell cultures and allogeneic tumor cells do so only in the presence of spleen cells. However, quiescent cell cultures display cytotoxicity in the presence of phytohemagglutinin A as do cell cultures which have lost their cytotoxic activity although they proliferate upon allogeneic stimulation. The significance of these findings is discussed." @default.
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- W1507899139 date "1976-06-01" @default.
- W1507899139 modified "2023-10-13" @default.
- W1507899139 title "Continuously Proliferating T Killer Cells Specific for H-2b Targets: Selection and Characterization" @default.
- W1507899139 doi "https://doi.org/10.4049/jimmunol.116.6.1601" @default.
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