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- W150790369 abstract "The mechanism of the internucleotide condensation and side-reactions in H-phosphonate approach has been investigated with the help of NMR-spectroscopy. On the basis of the results obtained a modification minimizing side-reactions in the course of the nucleotide component preactivation has been developed. It includes the use of acetonitrile--quinoline (4:1) mixture as the solvent in coupling reactions. The efficiency of the method is illustrated by the synthesis of oligodeoxynucleotides." @default.
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- W150790369 date "1990-02-01" @default.
- W150790369 modified "2023-09-24" @default.
- W150790369 title "[Modification of H-phosphonate method of oligonucleotide synthesis on polymer support]." @default.
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