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- W1508082018 abstract "Nucleoplasmin (NP) is a nuclear chaperone that mediates chromatin remodeling processes, such as sperm decondensation at fertilization [1]. In Xenopus laevis eggs, where it was first isolated, this highly acidic protein is thought to be in charge of nucleosomal core histones H2A/H2B storage. Upon fertilization, NP decondenses the densely packed sperm chromatin by means of extracting its specific basic proteins and replacing them with H2A/H2B, therefore enabling the assembly of somatic-type nucleosomes. NP is additionally involved in chromatin remodeling during early development, in particular it is required in the replication licensing mechanism, probably to extract linker-type histones from somatic chromatin, and can facilitate pluripotent cell reprogramming. NP (also designated NPM2) belongs to the nucleophosmin/nucleoplasmin family of histone chaperones [2]. Whereas NP roles have been particularly related to fertilization and embryogenesis, nucleophosmin (or NPM1) is ubiquitously and abundantly expressed in adult cells. It is enriched in the nucleolus, and serves multiple functions that affect cell growth and apoptosis, therefore disregulation of NPM1 is linked to several human cancers. Particular mutations of NPM1, that destabilize its structure, and cause its mislocalization to the cytoplasm, trigger acute myeloid leukaemia (AML). Apart from nucleophosmin and NP, the family includes the less known NPM3 and an invertebrate NPM-like." @default.
- W1508082018 created "2016-06-24" @default.
- W1508082018 creator A5000936450 @default.
- W1508082018 creator A5025919450 @default.
- W1508082018 creator A5032758369 @default.
- W1508082018 date "2013-01-23" @default.
- W1508082018 modified "2023-10-02" @default.
- W1508082018 title "Thermodynamic Signatures of Macromolecular Complexes ‒ Insights on the Stability and Interactions of Nucleoplasmin, a Nuclear Chaperone" @default.
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