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- W1508083472 abstract "Fetal alcohol spectrum disorder (FASD) is the leading cause of cognitive impairment in the Western world. The impact of the toxic effects of prenatal ethanol exposure (PNEE) on the development of memory regions of the brain remains unclear. To understand these effects, a rat model of PNEE was used to study structural elements of cornu ammonis 1 (CA1) of the hippocampus. Using light and electron microscopy, the density and size of pyramidal cell nuclei and synapses in the CA1 were quantified by morphometric methods in control and PNEE male rats at postnatal day 35 (P35). During gestation the blood alcohol content of pregnant dams ranged from 90-150 mg/dl and average body weight of PNEE offspring rats was ~15% less than controls at P35. By light microscopy, the pyramidal nuclear area (as a measure of cell body size) was reduced by ~22% in PNEE rats when compared to controls (105.1 ±15.1 µm² vs 135.2 ±4.65 µm²). By electron microscopy, the spine shape and density of synapses within stratum radiatum was not significantly different between the two groups, however, the total combined length of post-synaptic densities (PSDs) per test field (117µm²) was significantly less in PNEE rats (2157 ±121 nm vs 2523 ±192 nm, p<0.025, n=30 fields/group). These results indicate ethanol exposure in utero affects the size of pyramidal nuclei and overall receptive fields (PSDs) in adolescent PNEE rats and points to permanent effects or delays in maturation in the CA1 region of the hippocampus. Grant Funding Source: Supported by NSERC" @default.
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- W1508083472 date "2014-04-01" @default.
- W1508083472 modified "2023-09-26" @default.
- W1508083472 title "Prenatal ethanol exposure reduces pyramidal cell size and postsynaptic density length in the CA1 region of the hippocampus in adolescent rats (726.2)" @default.
- W1508083472 doi "https://doi.org/10.1096/fasebj.28.1_supplement.726.2" @default.
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