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- W1508093114 abstract "Asimetrik dimetil arjinin (ADMA) endojen Nitrik Oksit Sentaz enzimi (NOS) inhibitorudur. Ilk kez 1970 yillarinda metillenmis arjininler insan idrarinda saptanmistir. Ancak ADMA ile ilgili ilk calisma 1992’de Vallance ve arkadaslari tarafindan kronik bobrek yetmezligi hastalarinda yapilmistir. Son yillarda yapilan cok sayida calismada ADMA’nin endotel disfonksiyonu ve atherosklerozda rol aldigi ve belirtec olarak kullanilabilecegi bildirilmistir. ADMA’nin ayrica, bobrek yetmezligi, ateroskleroz, hiperglisemi, hiperhomosisteinemi durumlarinda da serumda yukseldigi tespit edilmistir. Biz bu derlemede ADMA’nin yapisi, sentezi, metabolizmasi ve klinik durumlar ile ilskisini inceleyecegiz." @default.
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- W1508093114 date "2015-02-23" @default.
- W1508093114 modified "2023-09-23" @default.
- W1508093114 title "Asimetrik Dimetil Arjinin (ADMA) Metabolizması" @default.
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