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- W1508127145 abstract "B76 Measurements of parameters such as apparent diffusion coefficient (ADC) of water and tissue Na + by magnetic resonance (MR) techniques have been suggested as noninvasive methods for predicting and/or monitoring response to therapy (1, 2). We and others have found that effective chemotherapy of subcutaneously (sc) implanted Radiation Induced Fibrosarcome (RIF-1) in mice with cyclophosphamide (1) and 5-fluorouracil (3), as well as, chemotherapy of intracranial 9L glioma in rats with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (1) correlate with increases in both total tumor tissue 23 Na signal intensity (SI) and water ADC in the first 3-5 post-treatment days. The most frequently cited hypothesis explaining an increase in tumor water ADC and 23 Na SI following therapy is that tumor cell death by apoptosis or necrosis invoke a net increase in extracellular space (ECS), an environment of assumed fast-diffusing water and high [Na + ] (1, 4). However, this clarification does not explain our results of BCNU treatment of sc-implanted 9L glioma. We have found that in sc-implanted 9L glioma 23 Na SI and water ADC significantly increase with growth in untreated control and non-responsive glioma, while in BCNU-responsive glioma both 23 Na SI and water ADC were almost unchanged (5). It appears the increase in water ADC and 23 Na SI after chemotherapy is not general phenomena resulting from an increase in ECS. Furthermore, in sc-implanted 9L glioma, Winter et al. (6) did not find any changes in the relative ECS, explaining the lower [Na + ] t in BCNU-treated tumors by improvement of tumor oxygenation and perfusion. We hypothesized that the different results in sc-implanted and intracranial glioma could be caused by location of tumors. However, Schepkin et al. recently reported the increase in water ADC and 23 Na SI in sc-implanted 9L glioma treated by BNCU (7). We assumed that the source of cell culture can play a role in different effects of BCNU. In our study, we used 9L cells from American Type Culture Collection (ATCC), while others (1, 7) used 9L cells from Brain Tumor Research Center, UCSF. Our preliminary results show a one week delay in the sc-growth of 9L glioma from ATCC compared to the tumor growth initiated by cells from UCSF. Additional estimation should be done to evaluate the possible role of type of anesthesia and tumor size in efficiency of BCNU treatment in experimental 9L glioma.References: (1) Schepkin et al. MRM, 53: 85-92, 2005; (2) Babsky et al. Neoplasia, 7: 658-66, 2005; (3) Babsky et al. ISMRM, p.1767, 2006; (4) Ross et al. Eur J Cancer, 38: 2147-56, 2002; (5) Babsky et al. JMRI, 24: 132-9, 2006; (6) Winter et al. Cancer Res 61: 2002-7, 2001; (7) Schepkin et al. MRI, 24: 273-8, 2006." @default.
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- W1508127145 date "2006-10-01" @default.
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- W1508127145 title "The problems of monitoring response to chemotherapy in subcutaneously implanted 9L glioma using apparent diffusion coefficient of water and 23Na magnetic resonance imaging" @default.
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