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- W1508145533 abstract "In the 1940’s, the development of penicillin as a potent broad-range antibiotic revolutionized the treatment of infectious disease and ushered in a prolific discovery period of natural small molecules produced by microorganisms that were antagonistic towards the growth of other bacteria. Antibiotics have generally been classified by their mechanism of action. For example, the β-lactam compounds, penicillin and cephalosporins, disrupt the synthesis of the peptidoglycan layer of the bacterial cell wall, whereas protein synthesis inhibitors, such as tetracycline and some aminoglycosides, bind to the 30S ribosomal subunit and block ad‐ dition of amino acids to the growing peptide chain. By the 1960’s, the majority of all antibi‐ otics in use today had been isolated and developed for public consumption, leading the U.S. Surgeon General to declare in 1968 that the war on infectious disease had been won." @default.
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- W1508145533 date "2013-01-23" @default.
- W1508145533 modified "2023-10-11" @default.
- W1508145533 title "Small Molecule Screens to Identify Inhibitors of Infectious Disease" @default.
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- W1508145533 doi "https://doi.org/10.5772/52502" @default.
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