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• W1508161657 abstract "This chapter discusses how the use of neurotropic viruses for analysis of brain organization has emerged from an integrated, multidisciplinary examination of the mechanisms that determine viral invasiveness. The focus is on the experimental use of pseudorabies virus (PRV), for two reasons. First, the attenuated strains of this virus have been widely used to study the organization of a variety of systems. Second, there is an ever-expanding literature in which well-documented models of PRV invasiveness have been used to probe the role of virally encoded proteins in viral invasiveness and virulence. The tropism and invasiveness of neurotropic viruses have been increasingly exploited in studies of the nervous system to define connections among ensembles of neurons. Recognition that neurotropic viruses might be useful for mapping neuronal circuitry emerged from the early studies that demonstrated that virus-induced neuropathology occurred in system-specific patterns. Neurons exhibit an enormous functional diversity, and this is reflected in the tremendous morphological diversity of different classes of neurons. Nevertheless, the fundamental aspects of cellular structure are common to all neurons, and some of these morphological features offer distinct advantages to a neurotropic pathogen." @default.
• W1508161657 created "2016-06-24" @default.
• W1508161657 creator A5028140472 @default.
• W1508161657 date "2001-01-01" @default.
• W1508161657 modified "2023-09-24" @default.
• W1508161657 title "Pseudorabies virus neuroinvasiveness: A window into the functional organization of the brain" @default.
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• W1508161657 doi "https://doi.org/10.1016/s0065-3527(01)56004-2" @default.
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