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- W1508317246 abstract "Polyelectrolytes assembled in a layer-by-layer fashion have been proposed for many applications, including those related to the biological interface. This chapter summarizes the findings of cell response to a spectrum of hydrophobic/hydrophilic surface charge. Surface hydrophilicity is usually probed via contact angle measurements. It shows water contact angles on ultrathin (four- or five-layered) combinations of various polymers. The chapter discusses the mobility and adhesion of cell over a range of polyelectrolyte multilayers (PEMUs) stiffness. Complex interrelationships between mechanosensing, adhesion, and motility enable some cell types to migrate along a modulus gradient through a process known as mechanotaxis or durotaxis. The chapter investigates control of cell adhesion and cell motility using biocompatible PEMUs with various uniform moduli and gradients of moduli. All PEMUs presented in the chapter were terminated with a cationic top layer of poly(allylamine) (PAH) to minimize effects of cationic and anionic surface charge differences." @default.
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- W1508317246 date "2015-01-21" @default.
- W1508317246 modified "2023-10-18" @default.
- W1508317246 title "The Interplay of Surface and Bulk Properties of Polyelectrolyte Multilayers in Determining Cell Adhesion" @default.
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- W1508317246 doi "https://doi.org/10.1002/9783527675869.ch2" @default.
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