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• W1508338047 startingPage "GRSB.S562" @default.
• W1508338047 abstract "Vitamin D receptor (VDR) and liver X receptor (LXR) are nuclear receptors, which regulate gene transcription upon binding of their specific ligands. VDR seems to play a role in the regulation of prostate cancer cell proliferation. ATP-binding cassette transporter A1 (ABCA1) is known to be a target gene of LXR and it has been reported to be inhibited by androgen and to be involved in the regulation of LNCaP proliferation. We find that calcitriol (1α,25(OH) 2 D 3 ) inhibits both basal and a LXR agonist, TO-901317, induced ABCA1 mRNA expression but has no effect on the mRNA expression of ATP-binding cassette transporter G1 (ABCG1), LXRα nor LXRβ TO-901317 increases both basal and calcitriol induced 25-hydroxyvitamin D 3 -24-hydroxylase (CYP24) mRNA expression and it slightly but significantly inhibits VDR mRNA expression. The inhibition of ABCA1 by calcitriol appears to be androgen-independent. Cell growth assay shows that when each of calcitriol and 5a-dihydrotestosterone (DHT) was co-treated with ABCA1 blocker, glybenclamide, cell-growth is significantly decreased compared to their own treatments respectively. Our study suggests a possible interaction between calcitriol and TO-901317 in LNCaP cells. Alike DHT, the inhibition of ABCA1 by calcitriol may be involved in its regulation of LNCaP growth." @default.
• W1508338047 created "2016-06-24" @default.
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• W1508338047 date "2008-01-01" @default.
• W1508338047 modified "2023-09-27" @default.
• W1508338047 title "Calcitriol and TO-901317 Interact in Human Prostate Cancer LNCaP Cells" @default.
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• W1508338047 doi "https://doi.org/10.4137/grsb.s562" @default.
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