FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1508362664> ?p ?o ?g. }

• W1508362664 endingPage "33" @default.
• W1508362664 startingPage "33" @default.
• W1508362664 abstract "Infection of intestinal epithelial cells by pathogenic Salmonella leads to activation of signaling cascades that ultimately initiate the proinflammatory gene program. The transcription factor NF-kappa B is a key regulator/activator of this gene program and is potently activated. We explored the mechanism by which Salmonella activates NF-kappa B during infection of cultured intestinal epithelial cells and found that flagellin produced by the bacteria and contained on them leads to NF-kappa B activation in all the cells; invasion of cells by the bacteria is not required to activate NF-kappa B.Purified flagellin activated the mitogen activated protein kinase (MAPK), stress-activated protein kinase (SAPK) and I kappa B kinase (IKK) signaling pathways that lead to expression of the proinflammatory gene program in a temporal fashion nearly identical to that of infection of intestinal epithelial cells by Salmonella. Flagellin expression was required for Salmonella invasion of host cells and it activated NF-kappa B via toll-like receptor 5 (TLR5). Surprisingly, a number of cell lines found to be unresponsive to flagellin express TLR5 and expression of exogenous TLR5 in these cells induces NF-kappa B activity in response to flagellin challenge although not robustly. Conversely, overexpression of dominant-negative TLR5 alleles only partially blocks NF-kappa B activation by flagellin. These observations are consistent with the possibility of either a very stable TLR5 signaling complex, the existence of a low abundance flagellin co-receptor or required adapter, or both.These collective results provide the evidence that flagellin acts as the main determinant of Salmonella mediated NF-kappa B and proinflammatory signaling and gene activation by this flagellated pathogen. In addition, expression of the fli C gene appears to play an important role in the proper functioning of the TTSS since mutants that fail to express fli C are defective in expressing a subset of Sip proteins and fail to invade host cells. Flagellin added in trans cannot restore the ability of the fli C mutant bacteria to invade intestinal epithelial cells. Lastly, TLR5 expression in weak and non-responding cells indicates that additional factors may be required for efficient signal propagation in response to flagellin recognition." @default.
• W1508362664 created "2016-06-24" @default.
• W1508362664 creator A5010932690 @default.
• W1508362664 creator A5022966422 @default.
• W1508362664 creator A5048868387 @default.
• W1508362664 creator A5064060535 @default.
• W1508362664 creator A5066313762 @default.
• W1508362664 creator A5083441292 @default.
• W1508362664 date "2004-01-01" @default.
• W1508362664 modified "2023-10-14" @default.
• W1508362664 cites W1519633296 @default.
• W1508362664 cites W1519843522 @default.
• W1508362664 cites W1526647481 @default.
• W1508362664 cites W1570011224 @default.
• W1508362664 cites W1653610611 @default.
• W1508362664 cites W1754406656 @default.
• W1508362664 cites W1925757606 @default.
• W1508362664 cites W1965971815 @default.
• W1508362664 cites W1966772446 @default.
• W1508362664 cites W1974245565 @default.
• W1508362664 cites W1979520552 @default.
• W1508362664 cites W1979973329 @default.
• W1508362664 cites W1993563092 @default.
• W1508362664 cites W2007009178 @default.
• W1508362664 cites W2011568956 @default.
• W1508362664 cites W2011843272 @default.
• W1508362664 cites W2016862474 @default.
• W1508362664 cites W2017012293 @default.
• W1508362664 cites W2017883909 @default.
• W1508362664 cites W2027983878 @default.
• W1508362664 cites W2033750976 @default.
• W1508362664 cites W2036475326 @default.
• W1508362664 cites W2037915962 @default.
• W1508362664 cites W2045384882 @default.
• W1508362664 cites W2058837791 @default.
• W1508362664 cites W2059687396 @default.
• W1508362664 cites W2063576137 @default.
• W1508362664 cites W2063742383 @default.
• W1508362664 cites W2075948284 @default.
• W1508362664 cites W2076201586 @default.
• W1508362664 cites W2076361525 @default.
• W1508362664 cites W2076613161 @default.
• W1508362664 cites W2077189992 @default.
• W1508362664 cites W2077296632 @default.
• W1508362664 cites W2077880395 @default.
• W1508362664 cites W2079968415 @default.
• W1508362664 cites W2087867048 @default.
• W1508362664 cites W2097747132 @default.
• W1508362664 cites W2098799418 @default.
• W1508362664 cites W2104402425 @default.
• W1508362664 cites W2105618135 @default.
• W1508362664 cites W2109890918 @default.
• W1508362664 cites W2114040309 @default.
• W1508362664 cites W2115235932 @default.
• W1508362664 cites W2116548822 @default.
• W1508362664 cites W2120457974 @default.
• W1508362664 cites W2121080125 @default.
• W1508362664 cites W2121952882 @default.
• W1508362664 cites W2122861283 @default.
• W1508362664 cites W2123006460 @default.
• W1508362664 cites W2124805544 @default.
• W1508362664 cites W2129291374 @default.
• W1508362664 cites W2130501069 @default.
• W1508362664 cites W2130840482 @default.
• W1508362664 cites W2132639360 @default.
• W1508362664 cites W2135038806 @default.
• W1508362664 cites W2137749186 @default.
• W1508362664 cites W2138067578 @default.
• W1508362664 cites W2138852428 @default.
• W1508362664 cites W2140611106 @default.
• W1508362664 cites W2145803213 @default.
• W1508362664 cites W2146098592 @default.
• W1508362664 cites W2160090062 @default.
• W1508362664 cites W2160805000 @default.
• W1508362664 cites W2162656620 @default.
• W1508362664 cites W2166078611 @default.
• W1508362664 cites W2169053713 @default.
• W1508362664 cites W2171260427 @default.
• W1508362664 cites W2171498110 @default.
• W1508362664 cites W2411875378 @default.
• W1508362664 cites W2490211911 @default.
• W1508362664 doi "https://doi.org/10.1186/1471-2180-4-33" @default.
• W1508362664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/516440" @default.
• W1508362664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15324458" @default.
• W1508362664 hasPublicationYear "2004" @default.
• W1508362664 type Work @default.
• W1508362664 sameAs 1508362664 @default.
• W1508362664 citedByCount "176" @default.
• W1508362664 countsByYear W15083626642012 @default.
• W1508362664 countsByYear W15083626642013 @default.
• W1508362664 countsByYear W15083626642014 @default.
• W1508362664 countsByYear W15083626642015 @default.
• W1508362664 countsByYear W15083626642016 @default.
• W1508362664 countsByYear W15083626642017 @default.
• W1508362664 countsByYear W15083626642018 @default.
• W1508362664 countsByYear W15083626642019 @default.
• W1508362664 countsByYear W15083626642020 @default.
• W1508362664 countsByYear W15083626642021 @default.

• next