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• W1508484106 abstract "This study investigated the effect of type 2 diabetes duration on glucose regulation 24 months post-bariatric surgery.Twenty-seven adults with short- (<5 years) and long-duration (≥10 years) type 2 diabetes received a mixed-meal tolerance test at baseline and 24 months postsurgery. Body weight, insulin sensitivity, first- and second-phase meal-stimulated insulin secretion, disposition index (i.e., DI or pancreatic β-cell function), and incretin responses were examined.Adults with short-duration type 2 diabetes had better HbA(1c), greater insulin secretory capacity, and greater DI compared with adults with long-duration type 2 diabetes, despite similar weight loss and incretin responses. Diabetes duration correlated with smaller improvements in HbA(1c) and DI but not weight loss.Enhanced β-cell function characterizes the effect of bariatric surgery in adults with diabetes for <5 years, independent of weight loss or incretins. Additional therapy postsurgery may be required to improve glycemia for people with long-standing type 2 diabetes." @default.
• W1508484106 created "2016-06-24" @default.
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• W1508484106 date "2015-02-03" @default.
• W1508484106 modified "2023-10-14" @default.
• W1508484106 title "Adults with long-duration type 2 diabetes have blunted glycemic and <i>β</i> -Cell function improvements after bariatric surgery" @default.
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• W1508484106 doi "https://doi.org/10.1002/oby.21021" @default.
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