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• W1508538805 abstract "Publisher Summary This chapter reviews a number of recent developments that have provided clues to the molecular mechanisms underlying the generation of polarity in neuronal cells. Neurons are divided broadly into two domains, the axonal domain and the somato-dendritic domain. These two domains differ in a number of features. Usually only one axon extends from the cell body; this long process is often unbranched or infrequently branched until it reaches its synaptic target, where it divides into fine branches with swellings at the pre-synaptic terminals that are the specialized sites for neurotransmitter release. Neurons contain many proteins known to play a role in intracellular targeting in other cell types, but for the most part the function of these proteins in neurons has not been directly tested. This is largely because of technical difficulties in obtaining sufficient amounts of purified populations of primary neurons for biochemical assays. Studies of neuronal polarity are dependent on molecular-biological approaches, such as the use of anti-sense oligonucleotides to inhibit the expression of known membrane-trafficking components and the use of viral vectors to express exogenous proteins." @default.
• W1508538805 created "2016-06-24" @default.
• W1508538805 creator A5014516188 @default.
• W1508538805 creator A5017746011 @default.
• W1508538805 date "1998-01-01" @default.
• W1508538805 modified "2023-09-27" @default.
• W1508538805 title "The Generation of Polarity in Neuronal Cells" @default.
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