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• W1508581642 abstract "Collagen based dressings for acute burn wound management have been extensively used in India, particularly in the city of Chennai. Due to the high levels of humidity in our city, closed dressings become infected and treatment with topical antimicrobials, like Silver Sulfadiazine cream, quickly become desiccated. Collagen membrane dressings were manufactured by the biomaterial laboratory of the Central Leather Research Institute (CLRI), Government of India in Chennai, and then the process was patented. Collagen was extracted from bovine skin and Achilles tendons, and then reconstituted. This was used on burn wounds as dressings after clearance from the Institutional Review Board and Ethics Committees of the Hospital and CLRI. Continued research in this field to enable resulted in the design of silver sulphadiazine loaded alginate microspheres which were embedded in the reconstituted collagen. Controlled delivery of silver sulphadiazine. This collagen membrane was used in chronic infected burns. Low molecular weight heparin was given subcutaneously to improve wound healing in burn injuries and collagen membrane dressings were also applied. After several trials the process technology was patented. The advantages and disadvantages of the collagen membrane cover is elaborated in a group of 487 pediatric burn patients. The trial was conducted at the burn unit of Kanchi Kamakoti Childs Trust Hospital (KKCTH) in Chennai, India. Pansements à base de collagène pour la gestion des blessures par brûlure ont été largement utilisés en Inde, en particulier dans la ville de Chennai. En raison des niveaux élevés d’humidité dans notre ville, les pansements fermées deviennent infectés et les traitements par les antimicrobiens topiques, comme la crème de sulfadiazine d’argent, deviennent vite desséchées. Le laboratoire de biomatériaux de l’Institut central de recherche sur le cuir (ICRC), gouvernement de l’Inde à Chennai, a fabriqué les pansements de membrane de collagène et le processus de fabrication a été breveté. Le collagène a été extrait de peau de bovin et de tendons d’Achille. Suite à l’autorisation de la commission de révision institutionnelle et les comités d’éthique de l’hôpital et l’ICRC, le collagène a été reconstitué et a été utilisé sur les brûlures comme pansements. Poursuite des recherches dans ce domaine a abouti à la conception des microsphères d’alginate chargées d’argent sulphadiazine qui ont été intégrées dans le collagène reconstitué. Cela a permis la libération contrôlée de sulfadiazine d’argent. Cette membrane de collagène a été utilisée dans les brûlures chroniques infectées. Les héparines de bas poids moléculaire ont été mises par injection sous-cutanée pour améliorer la cicatrisation des blessures par brûlure, et des pansements à membrane de collagène ont également été appliquées. Après plusieurs essais, la technologie de procédé a été breveté. Les avantages et les inconvénients de la couverture de la membrane de collagène est élaboré dans un groupe de 487 patients pédiatriques brûlés. Le procès s’est déroulé à l’unité des grands brûlés de l’hôpital Kanchi Kamakoti Childs Trust à Chennai, en Inde." @default.
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• W1508581642 date "2013-06-30" @default.
• W1508581642 modified "2023-09-22" @default.
• W1508581642 title "Advantages of collagen based biological dressings in the management of superficial and superficial partial thickness burns in children." @default.
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