Matches in SemOpenAlex for { <https://semopenalex.org/work/W150858778> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W150858778 endingPage "239" @default.
- W150858778 startingPage "227" @default.
- W150858778 abstract "The retinoblastoma protein (pRB) and the related pocket proteins, p107 and p130, play crucial roles in mammalian cell cycle control. Recent studies indicate that these pocket proteins are also involved in cellular differentiation processes. We demonstrate in this work that the pRB-related p130 selectively accumulates during the in vitro differentiation of the myeloid progenitor cell, 32Dcl3, into granulocyte in response to granulocyte-colony stimulating factor (G-CSF). This G-CSF-dependent granulocytic differentiation is blocked by the adenovirus E1A oncoprotein, which binds to and inactivates the pRB family of pocket proteins including p130. Furthermore, enforced overexpression of p130 but not pRB inhibits the myeloid cell proliferation that is concomitantly associated with granulocytic differentiation morphologically characterized by nuclear segmentation. However, simple G1-cell cycle arrest induced by cytokine deprivation or ectopic overexpression of the p27 cyclin-dependent kinase inhibitor, or inhibition of E2F activities by dominant negative DP-1 is not sufficient to trigger granulocytic differentiation. The differentiation-promoting activity of p130 in myeloid cells requires both the pocket domain and the spacer domain. Our results indicate that the pRB-related p130 plays a critical role in myeloid cell differentiation and suggest that coupling of cell cycle exit with the cellular differentiation program may be specifically achieved by p130." @default.
- W150858778 created "2016-06-24" @default.
- W150858778 creator A5002467761 @default.
- W150858778 creator A5034892457 @default.
- W150858778 creator A5053000890 @default.
- W150858778 creator A5061468745 @default.
- W150858778 creator A5085155039 @default.
- W150858778 creator A5087210528 @default.
- W150858778 date "1999-01-01" @default.
- W150858778 modified "2023-09-27" @default.
- W150858778 title "Granulocytic differentiation of myeloid progenitor cells by′ p130, the retinoblastoma tumor suppressor homologue." @default.
- W150858778 hasPublicationYear "1999" @default.
- W150858778 type Work @default.
- W150858778 sameAs 150858778 @default.
- W150858778 citedByCount "0" @default.
- W150858778 crossrefType "journal-article" @default.
- W150858778 hasAuthorship W150858778A5002467761 @default.
- W150858778 hasAuthorship W150858778A5034892457 @default.
- W150858778 hasAuthorship W150858778A5053000890 @default.
- W150858778 hasAuthorship W150858778A5061468745 @default.
- W150858778 hasAuthorship W150858778A5085155039 @default.
- W150858778 hasAuthorship W150858778A5087210528 @default.
- W150858778 hasConcept C104317684 @default.
- W150858778 hasConcept C148738053 @default.
- W150858778 hasConcept C1491633281 @default.
- W150858778 hasConcept C153911025 @default.
- W150858778 hasConcept C161879069 @default.
- W150858778 hasConcept C201750760 @default.
- W150858778 hasConcept C2776062698 @default.
- W150858778 hasConcept C2779282312 @default.
- W150858778 hasConcept C2780283210 @default.
- W150858778 hasConcept C28328180 @default.
- W150858778 hasConcept C29537977 @default.
- W150858778 hasConcept C502942594 @default.
- W150858778 hasConcept C54355233 @default.
- W150858778 hasConcept C62478195 @default.
- W150858778 hasConcept C83258922 @default.
- W150858778 hasConcept C86803240 @default.
- W150858778 hasConcept C95444343 @default.
- W150858778 hasConcept C95862172 @default.
- W150858778 hasConceptScore W150858778C104317684 @default.
- W150858778 hasConceptScore W150858778C148738053 @default.
- W150858778 hasConceptScore W150858778C1491633281 @default.
- W150858778 hasConceptScore W150858778C153911025 @default.
- W150858778 hasConceptScore W150858778C161879069 @default.
- W150858778 hasConceptScore W150858778C201750760 @default.
- W150858778 hasConceptScore W150858778C2776062698 @default.
- W150858778 hasConceptScore W150858778C2779282312 @default.
- W150858778 hasConceptScore W150858778C2780283210 @default.
- W150858778 hasConceptScore W150858778C28328180 @default.
- W150858778 hasConceptScore W150858778C29537977 @default.
- W150858778 hasConceptScore W150858778C502942594 @default.
- W150858778 hasConceptScore W150858778C54355233 @default.
- W150858778 hasConceptScore W150858778C62478195 @default.
- W150858778 hasConceptScore W150858778C83258922 @default.
- W150858778 hasConceptScore W150858778C86803240 @default.
- W150858778 hasConceptScore W150858778C95444343 @default.
- W150858778 hasConceptScore W150858778C95862172 @default.
- W150858778 hasLocation W1508587781 @default.
- W150858778 hasOpenAccess W150858778 @default.
- W150858778 hasPrimaryLocation W1508587781 @default.
- W150858778 hasRelatedWork W1549418259 @default.
- W150858778 hasRelatedWork W1928725833 @default.
- W150858778 hasRelatedWork W1956977862 @default.
- W150858778 hasRelatedWork W2019600656 @default.
- W150858778 hasRelatedWork W2043973033 @default.
- W150858778 hasRelatedWork W2049507532 @default.
- W150858778 hasRelatedWork W2050253043 @default.
- W150858778 hasRelatedWork W2060957264 @default.
- W150858778 hasRelatedWork W2071753279 @default.
- W150858778 hasRelatedWork W2079686761 @default.
- W150858778 hasRelatedWork W2086524102 @default.
- W150858778 hasRelatedWork W2093611259 @default.
- W150858778 hasRelatedWork W2116931996 @default.
- W150858778 hasRelatedWork W2142418810 @default.
- W150858778 hasRelatedWork W2375468400 @default.
- W150858778 hasRelatedWork W2416918934 @default.
- W150858778 hasRelatedWork W2419382317 @default.
- W150858778 hasRelatedWork W2897647651 @default.
- W150858778 hasRelatedWork W2979810486 @default.
- W150858778 hasRelatedWork W2785176409 @default.
- W150858778 hasVolume "1" @default.
- W150858778 isParatext "false" @default.
- W150858778 isRetracted "false" @default.
- W150858778 magId "150858778" @default.
- W150858778 workType "article" @default.