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- W1508658753 endingPage "S194" @default.
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- W1508658753 abstract "Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory deficits and other cognitive disturbances. Neuropathologically, AD is characterized by the progressive loss of basal forebrain cholinergic neurons that innervate the hippocampus and cortex and the abnormal extracellular accumulation of amyloid-β and intracellular tau protein. Current research on AD is focused on the mechanisms underlying the abnormal oligomerization, fibrillation, and accumulation of the amyloid-β and tau proteins, mechanisms that may alter the dynamics of this accumulation and on experimental therapeutics approaches aimed at the clearance of the abnormally folded proteins and other potentially neuroprotective interventions. This review will summarize the main areas of investigation in AD and present ways forward for future work." @default.
- W1508658753 created "2016-06-24" @default.
- W1508658753 creator A5074775445 @default.
- W1508658753 creator A5078691701 @default.
- W1508658753 date "2012-12-27" @default.
- W1508658753 modified "2023-09-27" @default.
- W1508658753 title "Alzheimer's Disease: Recent Advances and Future Perspectives" @default.
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