Matches in SemOpenAlex for { <https://semopenalex.org/work/W1508670918> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1508670918 endingPage "8" @default.
- W1508670918 startingPage "42" @default.
- W1508670918 abstract "The development of type 2 diabetes is associated with the impairment of insulin secretion. To evaluate the evolution of the secretory response, a chronological study comparing normal Wistar (W) vs Goto-Kakizaki (GK) rats, an animal model of non obese type 2 diabetes, was done. Glucose and arginine were tested in collagenase isolated islets of Langerhans with perfusion and ELISA immunoassay techniques. Fasting glycaemia and insulinemia and glucose tolerance were also evaluated. We have seen, in W rats, a mild glucose intolerance in the first two weeks of age. GK rats were always glucose intolerant with hyperglycaemia and hyperinsulinemia at fasten after one month old. Wistar islets had a characteristic biphasic response to glucose after the first two weeks of age. GK islets were always glucose irresponsive. Arginine induced an increase in insulin secretion in both animal models, independent of age, although GK rats had always a smaller response when compared to W rats. We concluded that 1) in W rats, a biphasic insulin secretion in response to glucose is observed after the first two weeks of age, simultaneously with glycaemia stabilization 2) in GK rats, both first and second phases of glucose-induced insulin release are significantly reduced and a smaller reduction in response to arginine is observed. This beta-cell disfunction is a primary event in this model of type 2 diabetes, preceding fasting hyperglycaemia and hyperinsulinemia." @default.
- W1508670918 created "2016-06-24" @default.
- W1508670918 creator A5002018324 @default.
- W1508670918 creator A5013626035 @default.
- W1508670918 creator A5076133971 @default.
- W1508670918 creator A5088899608 @default.
- W1508670918 date "2005-01-08" @default.
- W1508670918 modified "2023-09-23" @default.
- W1508670918 title "[Impaired insulin secretion in isolated islets of Goto-Kakizaki rats, an animal model of non obese type 2 diabetes, is a primary event]." @default.
- W1508670918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15636726" @default.
- W1508670918 hasPublicationYear "2005" @default.
- W1508670918 type Work @default.
- W1508670918 sameAs 1508670918 @default.
- W1508670918 citedByCount "3" @default.
- W1508670918 crossrefType "journal-article" @default.
- W1508670918 hasAuthorship W1508670918A5002018324 @default.
- W1508670918 hasAuthorship W1508670918A5013626035 @default.
- W1508670918 hasAuthorship W1508670918A5076133971 @default.
- W1508670918 hasAuthorship W1508670918A5088899608 @default.
- W1508670918 hasConcept C126322002 @default.
- W1508670918 hasConcept C134018914 @default.
- W1508670918 hasConcept C144855686 @default.
- W1508670918 hasConcept C165220095 @default.
- W1508670918 hasConcept C185592680 @default.
- W1508670918 hasConcept C2776828364 @default.
- W1508670918 hasConcept C2777180221 @default.
- W1508670918 hasConcept C2777391703 @default.
- W1508670918 hasConcept C2777468819 @default.
- W1508670918 hasConcept C2779306644 @default.
- W1508670918 hasConcept C2779855799 @default.
- W1508670918 hasConcept C2780988686 @default.
- W1508670918 hasConcept C3017594758 @default.
- W1508670918 hasConcept C3020574416 @default.
- W1508670918 hasConcept C515207424 @default.
- W1508670918 hasConcept C55493867 @default.
- W1508670918 hasConcept C555293320 @default.
- W1508670918 hasConcept C71924100 @default.
- W1508670918 hasConceptScore W1508670918C126322002 @default.
- W1508670918 hasConceptScore W1508670918C134018914 @default.
- W1508670918 hasConceptScore W1508670918C144855686 @default.
- W1508670918 hasConceptScore W1508670918C165220095 @default.
- W1508670918 hasConceptScore W1508670918C185592680 @default.
- W1508670918 hasConceptScore W1508670918C2776828364 @default.
- W1508670918 hasConceptScore W1508670918C2777180221 @default.
- W1508670918 hasConceptScore W1508670918C2777391703 @default.
- W1508670918 hasConceptScore W1508670918C2777468819 @default.
- W1508670918 hasConceptScore W1508670918C2779306644 @default.
- W1508670918 hasConceptScore W1508670918C2779855799 @default.
- W1508670918 hasConceptScore W1508670918C2780988686 @default.
- W1508670918 hasConceptScore W1508670918C3017594758 @default.
- W1508670918 hasConceptScore W1508670918C3020574416 @default.
- W1508670918 hasConceptScore W1508670918C515207424 @default.
- W1508670918 hasConceptScore W1508670918C55493867 @default.
- W1508670918 hasConceptScore W1508670918C555293320 @default.
- W1508670918 hasConceptScore W1508670918C71924100 @default.
- W1508670918 hasIssue "1" @default.
- W1508670918 hasLocation W15086709181 @default.
- W1508670918 hasOpenAccess W1508670918 @default.
- W1508670918 hasPrimaryLocation W15086709181 @default.
- W1508670918 hasRelatedWork W1508670918 @default.
- W1508670918 hasRelatedWork W1998101525 @default.
- W1508670918 hasRelatedWork W2016489785 @default.
- W1508670918 hasRelatedWork W2042617115 @default.
- W1508670918 hasRelatedWork W2058243996 @default.
- W1508670918 hasRelatedWork W2069395441 @default.
- W1508670918 hasRelatedWork W2073571766 @default.
- W1508670918 hasRelatedWork W2096706659 @default.
- W1508670918 hasRelatedWork W2129809791 @default.
- W1508670918 hasRelatedWork W2411110905 @default.
- W1508670918 hasVolume "17" @default.
- W1508670918 isParatext "false" @default.
- W1508670918 isRetracted "false" @default.
- W1508670918 magId "1508670918" @default.
- W1508670918 workType "article" @default.