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• W1508775395 abstract "DNA precursor biosynthesis is closely coordinated with DNA replication itself. In prokaryotic systems, firm evidence supports the idea that this coordination is achieved through the action of multienzyme complexes that physically link the synthesis of deoxyribonucleotides with their utilization in DNA replication. Much evidence favors a similar channeling mechanism in eukaryotes. However, recent studies suggest strongly that in mammalian cells DNA precursors are synthesized in cytoplasm and are then transported into the nucleus. This article reviews the pertinent evidence, attempts to reconcile contradictory findings, and highlights areas that need further investigation." @default.
• W1508775395 created "2016-06-24" @default.
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• W1508775395 date "1986-02-01" @default.
• W1508775395 modified "2023-09-25" @default.
• W1508775395 title "Eukaryotic DNA metabolism" @default.
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• W1508775395 doi "https://doi.org/10.1016/0014-4827(86)90335-6" @default.
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