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• W1508788245 abstract "A newly developed human immunoglobulin liquid preparation for intravenous injection was studied for efficacy, safety, and usefulness in treating severe and/or refractory infections in children receiving antibiotic treatment. It is suggested that C-425 is a useful intravenous preparation of human immunoglobulin for the treatment of severe and/or refractory infections in pediatrics. C-425 was administered to 87 inpatients with severe and/or refractory infections at 23 institutions nationwide. The Committee selected 61 cases for the present analysis. Physicians in charge judged clinical efficacy of C-425 to be excellent in 23 cases (40.4%), good in 24 (42.1%), fair in 7 (12.3%), poor in 3 (5.3%), and unknown in 4. The efficacy rate was calculated at 82.5% when the excellent and good cases were combined, and 94.7% when the fair cases were also included. According to the Committee's judgement, the efficacy of C-425 was excellent in 27 cases (44.3%), good in 18 (29.5%), fair in 7 (11.5%), and poor in 9 (14.8%). The efficacy rate was 73.8% when the excellent and good cases were combined. The rate increased to 85.2% when the fair cases were added. Organisms were identified in 31 cases, and the time course was followed in 19 instances. Organisms were eliminated in 12 cases (63.2%), decreased in number in 2 (10.5%), and persisted in 5 (26.3%). Eradication rate was 63.2%. One of the 87 patients died of fulminant hepatitis 2 days after the end of the treatment. The remaining 86 cases were analyzed for the safety of C-425. A skin rash was observed in one case. Laboratory examination revealed increase in transaminase levels in a total of 8 cases; both in GOT and GPT in 5, in GOT alone in 2, and in GPT alone in 1. These findings were not clinically important." @default.
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• W1508788245 date "1990-01-01" @default.
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• W1508788245 title "Therapeutic Evaluation of Combination Therapy using C-425, Human Native Immunoglobulin Liquid Preparation for i.v. Administration, and Antibiotics in Severe and/or Refractory Infections in Pediatrics" @default.
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• W1508788245 doi "https://doi.org/10.11150/kansenshogakuzasshi1970.64.34" @default.
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