Matches in SemOpenAlex for { <https://semopenalex.org/work/W150879800> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W150879800 endingPage "165" @default.
- W150879800 startingPage "159" @default.
- W150879800 abstract "The sex-dependent expression and growth hormone (GH) regulation of rat liver glutathione S-transferase (GST) was examined using oligonucleotide probes that distinguish between closely related class Alpha (Ya1, Ya2, Yc) and class Mu (Yb1, Yb2, Yb3) GST mRNAs [Waxman, Sundseth, Srivastava and Lapenson (1992) Cancer Res. 52, 5797-5802]. Northern-blot analysis revealed that the steady-state levels of GST Ya1, Yb1 and Yb2 mRNAs are 2.5-3-fold higher in male as compared with female rat liver. In contrast, GST Yc and Ya2 mRNAs were expressed at a 2-3-fold higher level in female rat liver. Microsomal GST mRNA did not exhibit significant sex-dependent differences in rat liver. Treatment of male rats with GH by continuous infusion suppressed expression of the male-dominant GST Ya1, Yb1 and Yb2 mRNAs to levels at or below those found in female rat liver. This suppressive effect of GH was liver-specific, insofar as GH treatment did not alter kidney GST Ya1 mRNA levels. Hypophysectomy increased expression of the male-dominant GSTs, particularly in female rats (e.g. 8-fold elevation of GST Ya1 mRNA). GST Yc mRNA was increased approx. 2-fold in hypophysectomized males, indicating that this mRNA is subject to negative regulation by one or more pituitary-dependent factors. Continuous GH treatment of the hypophysectomized rats suppressed the expression of mRNA of GSTs Ya1, Yb1 and Yb2 when given as a continuous infusion, but not when given by an intermittent (twice daily) GH-injection schedule. Combination of continuous exposure to GH with thyroxine treatment resulted in a more complete suppression of GSTs Ya1, Yb1 and Yb2. In contrast, thyroxine increased the expression of GST Yc in hypophysectomized rats. These studies establish that several Alpha and Mu class GSTs are expressed in a sex-dependent fashion in adult rat liver, where they are regulated by multiple pituitary-dependent hormones through pretranslational mechanisms." @default.
- W150879800 created "2016-06-24" @default.
- W150879800 creator A5044985980 @default.
- W150879800 creator A5052693377 @default.
- W150879800 date "1993-08-15" @default.
- W150879800 modified "2023-10-12" @default.
- W150879800 title "Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver" @default.
- W150879800 doi "https://doi.org/10.1042/bj2940159" @default.
- W150879800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134579" @default.
- W150879800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8363567" @default.
- W150879800 hasPublicationYear "1993" @default.
- W150879800 type Work @default.
- W150879800 sameAs 150879800 @default.
- W150879800 citedByCount "56" @default.
- W150879800 countsByYear W1508798002012 @default.
- W150879800 countsByYear W1508798002013 @default.
- W150879800 countsByYear W1508798002014 @default.
- W150879800 countsByYear W1508798002015 @default.
- W150879800 countsByYear W1508798002016 @default.
- W150879800 countsByYear W1508798002018 @default.
- W150879800 countsByYear W1508798002019 @default.
- W150879800 countsByYear W1508798002020 @default.
- W150879800 countsByYear W1508798002021 @default.
- W150879800 countsByYear W1508798002022 @default.
- W150879800 countsByYear W1508798002023 @default.
- W150879800 crossrefType "journal-article" @default.
- W150879800 hasAuthorship W150879800A5044985980 @default.
- W150879800 hasAuthorship W150879800A5052693377 @default.
- W150879800 hasBestOaLocation W1508798002 @default.
- W150879800 hasConcept C104317684 @default.
- W150879800 hasConcept C105580179 @default.
- W150879800 hasConcept C126322002 @default.
- W150879800 hasConcept C134018914 @default.
- W150879800 hasConcept C150194340 @default.
- W150879800 hasConcept C177707886 @default.
- W150879800 hasConcept C181199279 @default.
- W150879800 hasConcept C2776415932 @default.
- W150879800 hasConcept C2776907368 @default.
- W150879800 hasConcept C2780104272 @default.
- W150879800 hasConcept C538909803 @default.
- W150879800 hasConcept C55493867 @default.
- W150879800 hasConcept C71315377 @default.
- W150879800 hasConcept C71924100 @default.
- W150879800 hasConcept C86803240 @default.
- W150879800 hasConceptScore W150879800C104317684 @default.
- W150879800 hasConceptScore W150879800C105580179 @default.
- W150879800 hasConceptScore W150879800C126322002 @default.
- W150879800 hasConceptScore W150879800C134018914 @default.
- W150879800 hasConceptScore W150879800C150194340 @default.
- W150879800 hasConceptScore W150879800C177707886 @default.
- W150879800 hasConceptScore W150879800C181199279 @default.
- W150879800 hasConceptScore W150879800C2776415932 @default.
- W150879800 hasConceptScore W150879800C2776907368 @default.
- W150879800 hasConceptScore W150879800C2780104272 @default.
- W150879800 hasConceptScore W150879800C538909803 @default.
- W150879800 hasConceptScore W150879800C55493867 @default.
- W150879800 hasConceptScore W150879800C71315377 @default.
- W150879800 hasConceptScore W150879800C71924100 @default.
- W150879800 hasConceptScore W150879800C86803240 @default.
- W150879800 hasIssue "1" @default.
- W150879800 hasLocation W1508798001 @default.
- W150879800 hasLocation W1508798002 @default.
- W150879800 hasLocation W1508798003 @default.
- W150879800 hasOpenAccess W150879800 @default.
- W150879800 hasPrimaryLocation W1508798001 @default.
- W150879800 hasRelatedWork W1485204759 @default.
- W150879800 hasRelatedWork W173958657 @default.
- W150879800 hasRelatedWork W2038115351 @default.
- W150879800 hasRelatedWork W2067716481 @default.
- W150879800 hasRelatedWork W2335927495 @default.
- W150879800 hasRelatedWork W2365757350 @default.
- W150879800 hasRelatedWork W2465106682 @default.
- W150879800 hasRelatedWork W2471547905 @default.
- W150879800 hasRelatedWork W2589070882 @default.
- W150879800 hasRelatedWork W2725341754 @default.
- W150879800 hasVolume "294" @default.
- W150879800 isParatext "false" @default.
- W150879800 isRetracted "false" @default.
- W150879800 magId "150879800" @default.
- W150879800 workType "article" @default.