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- W1508828305 abstract "In the present study, we are focusing on regulation of serine phosphorylation of caveolin-2 in endothelial cells. We show that phosphorylation of caveolin-2 at serines 23 and 36 can be differentially regulated by caveolin-1 and in endothelial cells synchronized in mitosis. To directly address the role of caveolin-1 in regulating phosphorylation of endogenous caveolin-2, we have used siRNA approach. The specific knockdown of caveolin-1 in endothelial cells decreases caveolin-2 phosphorylation at serine 23 but not serine 36. Furthermore, immunofluorescence microscopy studies determined that serine 23-phosphorylated caveolin-2 mostly localizes to plasma membrane caveolae. Thus, upregulation of serine 23 phosphorylation of caveolin-2 depends on caveolin-1-driven targeting to plasma membrane caveolae. Interestingly, although, serine 36 phosphorylation does not seem to be regulated by caveolin-1, it can be selectively upregulated in endothelial cells synchronized in mitosis. The latter data suggests a possible involvement of serine 36-phosphorylated caveolin-2 in modulating endothelial cell cycle, in particular mitosis." @default.
- W1508828305 created "2016-06-24" @default.
- W1508828305 creator A5025841114 @default.
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- W1508828305 date "2008-03-01" @default.
- W1508828305 modified "2023-09-26" @default.
- W1508828305 title "Differential regulation of caveolin‐2 phosphorylation at serine 23 and 36 by caveolin‐1 and cell cycle in human endothelial cells." @default.
- W1508828305 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1048.10" @default.
- W1508828305 hasPublicationYear "2008" @default.
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