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• W1508833168 abstract "Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction. To develop an effective translational animal model that illuminates this interaction, daily seeking responses, maintained by alcohol-associated conditioned stimuli (CSs), need to be dissociated from alcohol drinking behavior. For this, we established a procedure whereby alcohol seeking maintained by alcohol-associated CSs is followed by a period during which rats have the opportunity to drink alcohol. This cue-controlled alcohol-seeking procedure was used to compare the effects of naltrexone and GSK1521498, a novel selective μ-opioid receptor antagonist, on both voluntary alcohol-intake and alcohol-seeking behaviors. Rederived alcohol-preferring, alcohol-nonpreferring, and high-alcohol-drinking replicate 1 line of rats (Indiana University) first received 18 sessions of 24 h home cage access to 10% alcohol and water under a 2-bottle choice procedure. They were trained subsequently to respond instrumentally for access to 15% alcohol under a second-order schedule of reinforcement, in which a prolonged period of alcohol-seeking behavior was maintained by contingent presentations of an alcohol-associated CS acting as a conditioned reinforcer. This seeking period was terminated by 20 min of free alcohol drinking access that achieved significant blood alcohol concentrations. The influence of pretreatment with either naltrexone (0.1−1−3 mg/kg) or GSK1521498 (0.1–1–3 mg/kg) before instrumental sessions was measured on both seeking and drinking behaviors, as well as on drinking in the 2-bottle choice procedure. Naltrexone and GSK1521498 dose-dependently reduced both cue-controlled alcohol seeking and alcohol intake in the instrumental context as well as alcohol intake in the choice procedure. However, GSK1521498 showed significantly greater effectiveness than naltrexone, supporting its potential use for promoting abstinence and preventing relapse in alcohol addiction." @default.
• W1508833168 created "2016-06-24" @default.
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• W1508833168 date "2015-06-05" @default.
• W1508833168 modified "2023-10-18" @default.
• W1508833168 title "The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking" @default.
• W1508833168 cites W1498082644 @default.
• W1508833168 cites W1570477602 @default.
• W1508833168 cites W1635084872 @default.
• W1508833168 cites W1963523021 @default.
• W1508833168 cites W1963841728 @default.
• W1508833168 cites W1965778413 @default.
• W1508833168 cites W1965983493 @default.
• W1508833168 cites W1969196954 @default.
• W1508833168 cites W1974449834 @default.
• W1508833168 cites W1976236173 @default.
• W1508833168 cites W1977546136 @default.
• W1508833168 cites W1978188503 @default.
• W1508833168 cites W1979025226 @default.
• W1508833168 cites W1985647606 @default.
• W1508833168 cites W1994066070 @default.
• W1508833168 cites W1996364982 @default.
• W1508833168 cites W1997881752 @default.
• W1508833168 cites W1999327472 @default.
• W1508833168 cites W2003495293 @default.
• W1508833168 cites W2003624018 @default.
• W1508833168 cites W2007591890 @default.
• W1508833168 cites W2008601574 @default.
• W1508833168 cites W2008878559 @default.
• W1508833168 cites W2012129826 @default.
• W1508833168 cites W2013922998 @default.
• W1508833168 cites W2014337202 @default.
• W1508833168 cites W2015046028 @default.
• W1508833168 cites W2016313834 @default.
• W1508833168 cites W2022180557 @default.
• W1508833168 cites W2028184368 @default.
• W1508833168 cites W2037528115 @default.
• W1508833168 cites W2043277296 @default.
• W1508833168 cites W2044305410 @default.
• W1508833168 cites W2048784641 @default.
• W1508833168 cites W2051401027 @default.
• W1508833168 cites W2051473277 @default.
• W1508833168 cites W2055826431 @default.
• W1508833168 cites W2059297425 @default.
• W1508833168 cites W2060941708 @default.
• W1508833168 cites W2066442810 @default.
• W1508833168 cites W2069573293 @default.
• W1508833168 cites W2073398764 @default.
• W1508833168 cites W2084016980 @default.
• W1508833168 cites W2086285100 @default.
• W1508833168 cites W2089691152 @default.
• W1508833168 cites W2091973738 @default.
• W1508833168 cites W2104538950 @default.
• W1508833168 cites W2120250480 @default.
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• W1508833168 doi "https://doi.org/10.1038/npp.2015.152" @default.
• W1508833168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4864633" @default.
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